...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the Royal Society. Biological sciences >A common suite of cellular abnormalities and spermatogenetic errors in sterile hybrid males in Drosophila
【24h】

A common suite of cellular abnormalities and spermatogenetic errors in sterile hybrid males in Drosophila

机译：果蝇中无菌杂种雄性常见的细胞异常和精子发生误差的常见套件

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

When two species interbreed, the resulting hybrid offspring are often sterile, with the heterogametic (e.g. XY) hybrid usually being more severely affected. The prevailing theory for this pattern of sterility evokes divergent changes in separate lineages having maladaptive interactions when placed together in a hybrid individual, with recessive factors on the sex chromosome interacting with dominant factors on the autosomes. The effect of these interactions on gametogenesis should not be uniform across species pairs unless genetic divergence follows the same paths in different lineages or if a specific stage of gametogenesis is more susceptible to detrimental genetic interactions. Here, we perform a detailed cellular characterization of hybrid male sterility across three recently diverged species pairs of Drosophila. Across all three pairs, sterile hybrid sperm are alive but exhibit rapid nuclear de-condensation with age, with active, but non-differentiated, mitochondria. Surprisingly, all three sets of interspecies hybrids produce half of the number of sperm per round of spermatogenesis, with each sperm cell containing two tails. We identify non-disjunction failures during meiosis I as the likely cause. Thus, errors during meiosis I may be a general phenomenon underlying Drosophila male sterility, indicating either a heightened sensitivity of this spermatogenic stage to failure, or a basis to sterility other than the prevailing model.
机译：当两个物种杂交中，所得的杂交后代通常是无菌的，杂种含量（例如XY）杂种通常更严重受到影响。这种无菌模式的普遍理论唤起，当在杂交个体中置于杂交个体中时，具有适应性相互作用的不同谱系的发散变化，性染色体的隐性因素与纯染色剂上的显性因子相互作用。这些相互作用对配子发生的影响在物种对中不应均匀，除非遗传分歧遵循不同谱系的相同路径，或者如果配子发生的特定阶段更容易受损遗传相互作用更容易受到影响。在这里，我们在最近分叉的三种果蝇对杂种雄性无菌的详细细胞表征。在所有三对，无菌杂交精子都活着，但随着年龄的增长，具有活跃但非分化的线粒体的快速核脱凝。令人惊讶的是，所有三组杂种杂交种产生每轮精子的一半，每个精子细胞含有两个尾巴。我们以可能的原因，我们在减数分裂时识别不分离的失败。因此，Meiosis中的误差我可能是果蝇雄性不育的一般现象，表明该精子遗传学阶段的敏感性的高度敏感性，或者除了普遍模型之外的无菌性的基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号