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首页> 外文期刊>Progress in Polymer Science >Flow behavior prior to crosslinking: The need for precursor rheology for placement of hydrogels in medical applications and for 3D bioprinting
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Flow behavior prior to crosslinking: The need for precursor rheology for placement of hydrogels in medical applications and for 3D bioprinting

机译：交联之前的流动性能：需要前体流变学，用于在医疗应用中放置水凝胶和3D生物印刷

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Hydrogels - water swollen crosslinked networks - have demonstrated considerable promise in tissue engineering and regenerative medicine applications. However, ambiguity over which rheological properties are needed to characterize these gels before crosslinking still exists. Most hydrogel research focuses on the performance of the hydrogel construct after implantation, but for clinical practice, and for related applications such as bioinks for 3D bioprinting, the behavior of the pre-gelled state is also critical. Therefore, the goal of this review is to emphasize the need for better rheological characterization of hydrogel precursor formulations, and standardized testing for surgical placement or 3D bioprinting. In particular, we consider engineering paste or putty precursor solutions (i.e., suspensions with a yield stress), and distinguish between these differences to ease the path to clinical translation. The connection between rheology and surgical application as well as how the use of paste and putty nomenclature can help to qualitatively identify material properties are explained. Quantitative rheological properties for defining materials as either pastes or putties are proposed to enable easier adoption to current methods. Specifically, the three-parameter Herschel-Bulkley model is proposed as a suitable model to correlate experimental data and provide a basis for meaningful comparison between different materials. This model combines a yield stress, the critical parameter distinguishing solutions from pastes (100-2000 Pa) and from putties (>2000 Pa), with power law fluid behavior once the yield stress is exceeded. Overall, successful implementation of paste or putty handling properties to the hydrogel precursor may minimize the surgeon-technology learning time and ultimately ease incorporation into current practice. Furthermore, improved understanding and reporting of rheological properties will lead to better theoretical explanations of how materials affect rheological performances, to better predict and design the next generation of biomaterials. (C) 2019 Elsevier B.V. All rights reserved.
机译：水凝胶 - 水肿胀的交联网络 - 在组织工程和再生医学应用中表现出相当大的承诺。然而，在交联之前需要在交联之前所需的流变性能来表征这些凝胶的模糊性。大多数水凝胶研究侧重于植入后水凝胶构建体的性能，但对于临床实践，以及用于3D生物印刷的生物链等相关应用，预凝胶状态的行为也是关键的。因此，本综述的目的是强调需要更好地改善水凝胶前体制剂的流变性表征，以及用于手术放置或3D生物监测的标准化测试。特别地，我们考虑工程糊或腻子前体溶液（即，具有屈服应力的悬浮液），并区分这些差异以缓解临床翻译的路径。流变学和手术应用之间的联系以及如何使用糊剂和腻子命名可以有助于定性地识别材料特性。提出了用于将材料定义为糊剂或粘性物质的定量流变性能，以便更容易地采用目前的方法。具体地，提出了三个参数Herschel-Bulkley模型作为相关的模型来关联实验数据，并为不同材料之间的有意义比较提供基础。该模型结合了屈服应力，从浆料（100-2000Pa）和Putties（> 2000Pa）中的关键参数区分解决方案，一旦超过屈服应力，电力法流体行为就能。总体而言，成功实施水凝胶前体的粘贴或腻子处理性能可以最大限度地减少外科医生技术学习时间，最终能够进入当前的实践。此外，改善了流变性质的理解和报告将导致材料如何影响流变性能的理论解释，更好地预测和设计下一代生物材料。 （c）2019年Elsevier B.V.保留所有权利。

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