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首页> 外文期刊>Progress in Artificial Intelligence >Extraintestinal Clostridioides difficile Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature
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Extraintestinal Clostridioides difficile Infections: Epidemiology in a University Hospital in Hungary and Review of the Literature

机译：Extraintepteintinalstridioides艰难梭菌感染：匈牙利大学医院流行病学和文学审查

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摘要

Extraintestinal manifestations of Clostridioides difficile infections (CDIs) are very uncommon, and according to the literature, poor outcomes and a high mortality have been observed among affected individuals. The objective of this study was to investigate the incidence rate of extraintestinal infections caused by C. difficile (ECD) in a tertiary-care university hospital in Hungary. During a 10-year study period, the microbiology laboratory isolated 4129 individual strains of C. difficile; among these, the majority were either from diarrheal fecal samples or from colonic material and only n = 24 (0.58%) were from extraintestinal sources. The 24 extraintestinal C. difficile isolates were recovered from 22 patients (female-to-male ratio: 1, average age: 55.4 years). The isolates in n = 8 patients were obtained from abdominal infections, e.g., appendicitis, rectal abscess or Crohn's disease. These extraintestinal cases occurred without concomitant diarrhea. In all, but two cases C. difficile was obtained as a part of a polymicrobial flora. Our isolates were frequently toxigenic and mostly belonged to PCR ribotype 027. Resistance to metronidazole, vancomycin, clindamycin and rifampin were 0%, 0%, 20.5% and 9.7%, respectively. The increasing amount of reports of C. difficile extraintestinal infections should be noted, as these infections are characterized by a poor outcome and high mortality rate.
机译：蛋白质酸纤维梭菌感染（CDIS）的外来表现非常罕见，并且根据文献，受影响的个体之间观察到差的结果和高死亡率。本研究的目的是探讨匈牙利第三级护理大学医院C.艰难岩（ECD）引起的含有蛋精感染的发病率。在10年期的研究期间，微生物学实验室分离4129个艰难菌株的C.差异;其中，大多数来自腹泻粪便样品或来自结肠材料，并且只有n = 24（0.58％）来自外来源。从22例患者（女性对雄性比例：1，平均年龄：55.4岁）中回收了24个uptianteminal c.艰难梭菌分离物。 N = 8名患者的分离物是从腹部感染，例如阑尾炎，直肠脓肿或克罗恩病中获得的。这些肾外病例没有伴随腹泻发生。总而言之，但是两种情况下C.艰难梭菌作为多元体菌群的一部分获得。我们的分离株经常是毒性，主要属于PCR丝溶型027.抗甲硝唑，万古霉素，克林霉素和利福平分别为0％，0％，20.5％和9.7％。应注意，C.艰难梭菌性感染的越来越多的报告。因为这些感染的特征在于差的结果和高死亡率。

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