...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Progress in Artificial Intelligence >Circulating Interleukin-6 is Associated with Skeletal Muscle Strength, Quality, and Functional Adaptation with Exercise Training in Mobility-Limited Older Adults
【24h】

Circulating Interleukin-6 is Associated with Skeletal Muscle Strength, Quality, and Functional Adaptation with Exercise Training in Mobility-Limited Older Adults

机译：循环白细胞介素-6与骨骼肌强度，质量和功能适应有关的流动性训练有关，在流动性限制的老年人中有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Human aging is characterized by a chronic, low-grade inflammation suspected to contribute to reductions in skeletal muscle size, strength, and function. Inflammatory cytokines, such as interleukin-6 (IL-6), may play a role in the reduced skeletal muscle adaptive response seen in older individuals. Objectives To investigate relationships between circulating IL-6, skeletal muscle health and exercise adaptation in mobility-limited older adults. Design Randomized controlled trial. Setting Exercise laboratory on the Health Sciences campus of an urban university. Participants 99 mobility-limited (Short Physical Performance Battery (SPPB) <= 9) older adults. Intervention 6-month structured physical activity with or without a protein and vitamin D nutritional supplement. Measurements Circulating IL-6, skeletal muscle size, composition (percent normal density muscle tissue), strength, power, and specific force (strength/CSA) as well as physical function (gait speed, stair climb time, SPPB-score) were measured pre- and post-intervention. Results At baseline, Spearman's correlations demonstrated an inverse relationship (P<0.05) between circulating IL-6 and thigh muscle composition (r = -0.201), strength (r = -0.311), power (r = -0.210), and specific force (r = -0.248), and positive association between IL-6 and stair climb time (r = 0.256; P<0.05). Although the training program did not affect circulating IL-6 levels (P=0.69), reductions in IL-6 were associated with gait speed improvements (r = -0.487; P<0.05) in "higher" IL-6 individuals (>1.36 pg/ml). Moreover, baseline IL-6 was inversely associated (P<0.05) with gains in appendicular lean mass and improvements in SPPB score (r = -0.211 and -0.237, respectively). Conclusions These findings implicate age-related increases in circulating IL-6 as an important contributor to declines in skeletal muscle strength, quality, function, and training-mediated adaptation. Given the pervasive nature of inflammation among older adults, novel therapeutic strategies to reduce IL-6 as a means of preserving skeletal muscle health are enticing.
机译：背景技术人衰老的特征是患有慢性低，低级炎症，可导致骨骼肌大小，强度和功能减少。炎症细胞因子，例如白细胞介素-6（IL-6），可能在老年人中看到的降低的骨骼肌适应性反应中发挥作用。目的探讨循环IL-6，骨骼肌健康和运动适应在流动性的老年​​人之间的关系。设计随机对照试验。在城市大学卫生科学校园设定运动实验室。参与者99流动限制（短物理性能电池（SPPB）<= 9）老年人。干预6个月结构化体育活动或没有蛋白质和维生素D营养补充剂。测量循环IL-6，骨骼肌尺寸，成分（均匀密度肌肉组织百分比），强度，功率和特定力（强度/ CSA）以及物理功能（步态速度，阶段爬升时间，SPPB评分）前期和干预后。结果在基线时，Spearman的相关性证明了循环IL-6和大腿肌肉组合物（R = -0.201），强度（R = -0.311），功率（R = -0.210）和特定力之间的反比关系（P <0.05） （r = -0.248），IL-6与阶段之间的阳性关联（r = 0.256; p <0.05）。虽然培训计划没有影响循环IL-6水平（p = 0.69），但在“高于”IL-6个体中，IL-6的减少与步态速度改进（R = -0.487; p <0.05）相关联（> 1.36 pg / ml）。此外，基线IL-6与阑尾瘦肿块（P <0.05）相关（P <0.05），并且SPPB得分的改善（分别为-0.211和-0.237）。结论这些发现牵引与血液肌肉力量，质量，功能和培训介导适应下降的重要贡献者的年龄相关的增加。鉴于老年人炎症的普遍性，降低IL-6的新的治疗策略作为保护骨骼肌健康的手段是诱人的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号