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Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson's Disease

机译：帕金森病故事中的昼夜节律，神经炎炎症和氧化应激

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摘要

Parkinson's disease (PD) is one of the main neurodegenerative disease characterized by a progressive degeneration of neurons constituted by dopamine in the substantia nigra pars compacta. The etiologies of PD remain unclear. Aging is the main risk factor for PD. Aging could dysregulate molecular pathways controlling cell homeostatic mechanisms. PD cells are the sites of several metabolic abnormalities including neuroinflammation and oxidative stress. Metabolic structures are driven by circadian rhythms. Biologic rhythms are complex systems interacting with the environment and controlling several physiological pathways. Recent findings have shown that the dysregulation of the circadian rhythms is correlated with PD and its metabolic dysregulations. This review is focused on the key role of circadian rhythms and their impact on neuroinflammation and oxidative stress in Parkinson's disease.
机译：帕金森病（PD）是主要的神经退行性疾病之一，其特征在于，在Implia Nigra ParsCompacta中的多巴胺构成的神经元进行了渐变。 PD的病因仍然不清楚。 老化是PD的主要风险因素。 衰老能够厌氧控制细胞稳态机制的分子途径。 Pd细胞是几种代谢异常的位点，包括神经炎症和氧化应激。 代谢结构由昼夜节律驱动。 生物节律是与环境相互作用的复杂系统，并控制几种生理途径。 最近的发现表明，昼夜节律的失调与PD及其代谢功能中的功能相关。 该审查专注于昼夜节律的关键作用及其对帕金森病中的神经炎炎症和氧化胁迫的影响。

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