Insights into Systemic Disease through Retinal Imaging-Based Oculomics

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Insights into Systemic Disease through Retinal Imaging-Based Oculomics

机译：通过视网膜成像的血管组学探讨了全身疾病

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Among the most noteworthy developments in ophthalmology over the last decade has been the emergence of quantifiable high-resolution imaging modalities, which are typically non-invasive, rapid and widely available. Such imaging is of unquestionable utility in the assessment of ocular disease however evidence is also mounting for its role in identifying ocular biomarkers of systemic disease, which we term oculomics. In this review, we highlight our current understanding of how retinal morphology evolves in two leading causes of global morbidity and mortality, cardiovascular disease and dementia. Population-based analyses have demonstrated the predictive value of retinal microvascular indices, as measured through fundus photography, in screening for heart attack and stroke. Similarly, the association between the structure of the neurosensory retina and prevalent neurodegenerative disease, in particular Alzheimer's disease, is now well-established. Given the growing size and complexity of emerging multimodal datasets, modern artificial intelligence techniques, such as deep learning, may provide the optimal opportunity to further characterize these associations, enhance our understanding of eye-body relationships and secure novel scalable approaches to the risk stratification of chronic complex disorders of ageing.

机译：在过去十年中，眼科的最值得关注的发展是可量化的高分辨率成像方式的出现，通常是非侵入性的，快速和广泛的可用性。这种成像在对眼部疾病的评估中具有毫无疑问的效用，但是证据也在鉴定全身疾病的眼科患者中的作用，我们术语动眼症。在这篇综述中，我们强调了我们目前在全球发病率和死亡率，心血管疾病和痴呆症的两种主要原因中发展的理解。基于人口的分析已经证明了通过眼底摄影来筛选心脏病发作和中风的视网膜微血管指数的预测值。类似地，目前，神经感应视网膜和普遍的神经变性疾病的结构之间的关联现在已经确定。鉴于新出现的多式联运数据集的规模和复杂性不断增长，现代人工智能技术，如深度学习，可以提供进一步表征这些协会的最佳机会，增强我们对人身体关系的理解，并确保对风险分层的新颖可扩展方法慢性复杂疾病的老化。

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《Progress in Artificial Intelligence》 |2020年第2期|共10页
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正文语种 eng
中图分类计算技术、计算机技术;
关键词
deep learning; artificial intelligence; optical coherence tomography;

机译：深入学习;人工智能;光学相干断层扫描;

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1. Insights into Systemic Disease through Retinal Imaging-Based Oculomics [J] . Progress in Artificial Intelligence . 2020,第2期

机译：通过视网膜成像的血管组学探讨了全身疾病
2. Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood-retinal barrier. [J] . Hosoya K, Tomi M, Tachikawa M Expert opinion on drug delivery . 2011,第12期

机译：使用全身性药物递送治疗视网膜疾病的策略：血视网膜屏障中转运蛋白的相关性。
3. REVIEW Small Vessels-Big Problems: Novel Insights into Microvascular Mechanisms of Diseases: Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases [J] . Delia Cabrera DeBuc, Gabor Mark Somfai, Akos Roller American Journal of Physiology . 2017,第2aPta2期

机译：审查小船只 - 大问题：对微血管疾病的新见解：视网膜微血管网络改变：脑血管血管和神经疾病的潜在生物标志物
4. Retinal Biomarkers of Alzheimer's Disease: Insights from Transgenic Mouse Models [C] . Rui Bernardes, Gilberto Silva, Samuel Chiquita, International conference on image analysis and recognition . 2017

机译：阿尔茨海默氏病的视网膜生物标志物：转基因小鼠模型的见解
5. The Retinal Immune Response to Injury and Protein Misfolding: Insights from Models of Traumatic Brain Injury, Parkinson’s Disease, and Prion Disease [D] . Mammadova, Najiba 2019

机译：视网膜对损伤和蛋白质错误折叠的免疫反应：创伤性脑损伤，帕金森氏病和Pri病毒病模型的启示
6. Insights into Systemic Disease through Retinal Imaging-Based Oculomics [O] . Siegfried K. Wagner, Dun Jack Fu, Livia Faes, -1

机译：通过基于视网膜成像的眼球组学洞察系统性疾病
7. HIT Poster session 1P154Preclinical diastolic dysfunction is related to impaired endothelial function in patients with chronic kidney diseaseP155Early detection of left atrial and left ventricular abnormalities in hypertensive and obese womenP156Right ventricle preserved systolic function irrespective of right ventricular hypertrophy and disease severity in anderson fabry diseaseP157Left atrial volume and function in patients undergoing percutaneous mitral valve repairP158Impact of left ventricular dysfunction on outcomes of patients undergoing direct TAVI with a self-expanding bioprosthesisP159Anatomic Doppler spectrum – retrospective spectral tissue Doppler from ultra high frame rate tissue Doppler imaging for evaluation of tissue deformationP160Phasic dynamics of ischaemic mitral regurgitation after primary coronary intervention in acute myocardial infarction: serial echocardiographic assessment from emergency room to long-term follow-upP161Reproducibility of 3DE RV volumes - novel insights at a regional levelP162Pulmonary vascular capacitance as assessed by echocardiography in pulmonary arterial hypertensionP163Three-dimensional endocardial area strain: a novel parameter for quantitative assessment of global left ventricular systolic functionP164Role of exercise hemodynamics assessed by echocardiography on symptom reduction after MitraClipP165Early identification of ventricular dysfunction in patients with juvenile systemic sclerosisP166Heart failure with and without preserved ejection fraction - the role of biomarkers in the aspect of global longitudinal strainP167Complex systolic deformation of aortic root: insights from two dimensional speckle tracking imageP168Volumetric and deformational imaging usind 2d strain and 3d echocardiography in patients with pulmonary hypertensionP169Influence of pressure load and right ventricular morphology and function on tricuspid regurgitation in pulmonary arterial hypertensionP170Left ventricular myocardial diastolic deformation analysis by 2D speckle tracking echocardiography and relationship with conventional diastolic parameters in chronic aortic regurgitationP171Extracellular volume, and not native T1 time, distinguishes diffuse fibrosis in dilated or hypertrophic cardiomyopathy at 3TP172Left atrial strain is significantly reduced in arterial hypertensionP173Symptomatic severe secondary mitral regurgitation: LV enddiastolic diameter (LVEDD) as preferable parameter for risk stratificationP174Left ventricular mechanics in isolated left bundle branch block at rest and when exercising: exploration of the concept of conductive cardiomyopathyP175Assessment of myocardial scar by 2D contrast echocardiographyP176Chronic pericarditis - expression of a rare disease: Erdheim Chester diseaseP177Aortic arch mechanics with two-dimensional speckle tracking echocardiography to estimate the left ventricular remodelling in hypertensive patientsP178Strain analysis by tissue doppler imaging: comparison of conventional manual measurement with a semi-automated approachP179Distribution of extravascular lung water in heart failure patients assessed by lung ultrasoudP180Surrogate markers for obstructive coronary artery diseaseP181LA deformation and LV longitudinal strain by two-dimensional speckle tracking echocardiography as predictors of postoperative AF development after aortic valve replacement in ASP182Left ventricular diastolic dysfunction in type 2 diabetic patients with non alcoholic fatty liver diseaseP183Myocardial strain by speckle-tracking and evaluation of 3D ejection fraction in drug-induced cardiotoxicity's approach in breast cancer [O] . AB Gevaert, A Borizanova, F Graziani, 2015

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Insights into Systemic Disease through Retinal Imaging-Based Oculomics

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