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首页> 外文期刊>Progress in Artificial Intelligence >The Singularity of the Drosophila Male Germ Cell Centriole: The Asymmetric Distribution of Sas4 and Sas6
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The Singularity of the Drosophila Male Germ Cell Centriole: The Asymmetric Distribution of Sas4 and Sas6

机译：果蝇雄性生殖细胞离心机的奇异性：SAS4和SAS6的不对称分布

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Drosophila spermatocytes have giant centrioles that display unique properties. Both the parent centrioles maintain a distinct cartwheel and nucleate a cilium-like region that persists during the meiotic divisions and organizes a structured sperm axoneme. Moreover, the parent centrioles are morphologically undistinguishable, unlike vertebrate cells in which mother and daughter centrioles have distinct structural features. However, our immunofluorescence analysis of the parent centrioles in mature primary spermatocytes revealed an asymmetric accumulation of the typical Sas4 and Sas6 proteins. Notably, the fluorescence intensity of Sas4 and Sas6 at the daughter centrioles is greater than the intensity found at the mother ones. In contrast, the centrioles of wing imaginal disc cells display an opposite condition in which the loading of Sas4 and Sas6 at the mother centrioles is greater. These data underlie a subtle asymmetry among the parent centrioles and point to a cell type diversity of the localization of the Sas4 and Sas6 proteins.
机译：果蝇精子细胞具有巨大的半硅基，呈现独特的性质。母体酰缀均含有不同的车轮，核心含有类似的硅藻土区域，其在减数分子分区期间持续存在并组织结构化精子轴突。此外，母体含乙醇是形态学上不可替补的，与脊椎动物细胞不同，其中母体和女儿偏纤维具有不同的结构特征。然而，我们在成熟的初级精子细胞中对母体半硅酸酯的免疫荧光分析显示出典型的SAS4和SAS6蛋白的不对称积累。值得注意的是，女儿厘摩洛瑞瑞斯的SAS4和SAS6的荧光强度大于在母亲中发现的强度。相反，翼状椎间盘线细胞的半硅烷显示出相反的条件，其中母线摩洛尔的SAS4和SAS6的负载更大。这些数据在母体含硅酸酯中具有微妙的不对称性，并指向SAS4和SAS6蛋白的定位的细胞型多样性。

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