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首页> 外文期刊>Prostaglandins and Other Lipid Mediators >Effect of central and peripheral injection of prostaglandin E2 and F2 alpha on feeding and the crop-emptying rate in chicks
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Effect of central and peripheral injection of prostaglandin E2 and F2 alpha on feeding and the crop-emptying rate in chicks

机译：前列腺素E2和F2α中的中枢和外周注射对小鸡喂养和作物排空率的影响

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Prostaglandins (PGs) have been shown to cause several physiological changes in mammals including anorexia, awakening and sleeping, change in digestive function, and activation of the hypothalamus-pituitary-adrenal gland (HPA) axis. However, there is a paucity of information about the effect of PGs on physiological parameters in birds. The purpose of the present study was to clarify whether intracerebroventricular (ICV) and intraperitoneal (IP) injections of prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2 alpha) affect feeding, voluntary movement, crop-emptying rate, and corticosterone release in chicks (Gallus gallus). ICV injection of either PGE2 or PGF2 alpha (2 and 4 mu g) significantly decreased food intake in chicks. The anorexigenic effect was also observed after IP injection of the PGs. Voluntary movement was significantly suppressed by ICV injection of PGE2 or PGF2 alpha, although the time-course change was different between the two. In contrast, IP injection of the PGs had no or less effect on voluntary movement. Both ICV and IP injection of PGE2 significantly retarded the crop-emptying rate, whereas PGF2 alpha significantly lowered the crop-emptying rate only after IP injection. The plasma corticosterone concentration significantly increased after ICV and IP injection of PGE2, whereas PGF2 alpha had no effect. These results suggest that central and peripheral PGs are involved in the regulation of appetite, voluntary movement, food passage in the digestive tract, and activation of the HPA axis in chicks, although the effects depend on the site of action and type of PGs.
机译：已显示前列腺素（PGS）导致哺乳动物中的若干生理变化，包括厌食，觉醒和睡眠，消化功能的变化，以及下丘脑 - 垂体 - 肾上腺（HPA）轴的激活。然而，缺乏关于PGS对鸟类生理参数影响的信息。本研究的目的是阐明脑内（ICV）和腹膜内（IP）注射前列腺素E2（PGE2）和前列腺素F2α（PGF2α）影响饲料，自愿运动，作物排空率和小鸡中的皮质酮释放（Gallus Gallus）。 ICV注射PGE2或PGF2α（2和4μg）显着降低了小鸡的食物摄入量。在IP注射PGS后也观察到厌恶效应。 ICV注射PGE2或PGF2α显着抑制自愿运动，尽管两者之间的时间变化不同。相比之下，对PG的IP注射对自愿运动没有或更少的影响。 ICV和IP注射的PGE2都显着延迟了作物排空率，而PGF2 alpha仅在IP注射后显着降低了作物排空率。在ICV和IP注射PGE2后，血浆皮质酮浓度显着增加，而PGF2α无效。这些结果表明，中央和外周PGS参与了食欲，自愿运动，消化道中的食物通道的调节，以及在雏鸡中激活HPA轴，尽管效果取决于动作部位和PGS的类型。

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