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首页> 外文期刊>Psychogeriatrics : >The usefulness of combined brain perfusion single‐photon emission computed tomography, Dopamine‐transporter single‐photon emission computed tomography, and 123 123 I‐metaiodobenzylguanidine myocardial scintigraphy for the diagnosis of dementia with Lewy bodies
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The usefulness of combined brain perfusion single‐photon emission computed tomography, Dopamine‐transporter single‐photon emission computed tomography, and 123 123 I‐metaiodobenzylguanidine myocardial scintigraphy for the diagnosis of dementia with Lewy bodies

机译：组合脑灌注单光子发射计算机断层扫描的有用性，多巴胺 - 转运蛋白单光子发射计算断层扫描，123 123酮二碘苄基胍氨基氨基透明度用于诊断痴呆症与石油尸体

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Background Current diagnostic criteria recommend neuroimaging as a diagnostic support tool for the clinical diagnosis of dementia with Lewy bodies (DLB). Because DLB causes characteristic impairments and disabilities, such as neuroleptic hypersensitivity, which may significantly increase morbidity and mortality, its prompt and correct diagnosis is very important. The aim of this study was to evaluate the extent to which diagnostic accuracy can be increased by using different combinations of brain perfusion single‐photon emission computed tomography (bp‐SPECT), 123 I‐metaiodobenzylguanidine myocardial scintigraphy (MIBG scintigraphy), and DAT‐SPECT. Taking finances and patient burden into consideration, we compared the tests to determine priority. Methods Thirty‐four patients with probable DLB (75.0 ± 8.3 years old; 14 men, 20 women) underwent bp‐SPECT, MIBG scintigraphy, and DAT‐SPECT. Results Our comparison of three functional imaging techniques indicated that MIBG scintigraphy (79%) and Dopamine‐transporter (DAT) SPECT (79%) had better sensitivity for characteristic abnormalities in DLB than bp‐SPECT (53%). The combination of the three modalities could increase sensitivity for diagnosis of DLB to 100%. Additionally, the ratio of patients with rapid eye movement sleep behaviour disorder was significantly higher in the positive finding group on MIBG scintigraphy than in the negative finding group. Conclusions In terms of stand‐alone diagnostic means, priority should be placed on MIBG scintigraphy or DAT‐SPECT for the diagnosis of DLB. However, our results suggest that the combination of bp‐SPECT, MIBG scintigraphy, and DAT‐SPECT increased the accuracy of the clinical diagnosis of DLB.
机译：背景技术当前诊断标准建议NeuroMimaging作为诊断支持工具，用于患有石油体（DLB）的痴呆症的临床诊断。因为DLB导致特征障碍和残疾，例如神经抑制过敏，这可能显着提高发病率和死亡率，其提示和正确的诊断非常重要。本研究的目的是通过使用脑灌注单光子发射计算机断层摄影（BP-SPECT）的不同组合来评估可以提高诊断准确度的程度，123酮碘苄基胍氨基氨基（MIBG SCINTIGRAWHY）和DAT- spect。考虑财务和患者负担，比较测试以确定优先权。方法有三十四名有可能的DLB患者（75.0±8.3岁; 14名男子，20名女性）接受了BP-SPECT，MIBG Scintigraphy和Dat-Spect。结果我们对三种功能成像技术的比较表明，MIBG Scintigraphy（79％）和多巴胺 - 转运蛋白（DAT）SPECT（79％）对DLB的特征异常具有比BP-SPECT（53％）更好的敏感性。三种方式的组合可以增加诊断DLB至100％的敏感性。此外，MIBG Scintigraphy阳性发现组患者患者快速的眼睛运动睡眠行为障碍的患者的比例显着高于阴性发现组。结论在独立诊断手段方面，应优先于MIBG Scintigraphy或Dat-Spect进行DLB的诊断。然而，我们的结果表明，BP-SPECT，MIBG Scintaphy和DAT-SPECT的组合提高了DLB临床诊断的准确性。

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