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首页> 外文期刊>Psychopharmacology >Stereoselective effects of the second-generation synthetic cathinone -pyrrolidinopentiophenone (-PVP): assessments of conditioned taste avoidance in rats
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Stereoselective effects of the second-generation synthetic cathinone -pyrrolidinopentiophenone (-PVP): assessments of conditioned taste avoidance in rats

机译：第二代合成胆醌 - 吡咯烷酮酮（-PVP）的立体选择作用：大鼠条件避免调节味道的评估

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RationaleWork with -pyrrolidinopentiophenone (-PVP), a second-generation synthetic cathinone, has been generally limited to the racemate. Given that with other synthetic cathinones, there are behavioral and neurochemical differences between their enantiomers, differences may also be seen with -PVP.ObjectivesThe present study assessed the relative contribution of each enantiomer to the aversive effects of racemic--PVP by comparing their ability to induce a conditioned taste avoidance.MethodsAdult male Sprague-Dawley rats were exposed every other day for four exposures to a novel saccharin solution followed immediately by an injection of 0 (saline vehicle) or 1.5, 3, or 6mg/kg of S-, R-, or racemic--PVP (IP). On alternating days, all subjects were given access to water to assess any unconditioned effects of -PVP on general fluid consumption.ResultsRats injected with the racemate and S-isomer of -PVP displayed avoidance of the drug-associated saccharin solution, although this avoidance was dose-dependent only for the subjects injected with the racemate. There was no evidence of taste avoidance in animals injected with the R-enantiomer at any dose tested. Animals injected with 3mg/kg racemic--PVP did not differ in avoidance from those treated with 1.5mg/kg of the S-enantiomer, but subjects treated with 6mg/kg racemic--PVP displayed a significantly stronger avoidance than those treated with 3mg/kg S--PVP.ConclusionsThe present work suggests that the aversive effects of racemic -PVP are mediated primarily by its S-isomer. The fact that at the highest dose tested (6mg/kg), the racemate induces an avoidance greater than the simple additive effects of the S- and R-isomers (at 3mg/kg) suggests that while the R-isomer may not induce taste avoidance at this dose, it may interact synergistically with the S-isomer in mediating the effects of the racemic mixture. These results were discussed in terms of similar effects with other behavioral and physiological endpoints reported with a number of psychostimulants and suggest that the enantiomers of -PVP are an important variable in characterizing its behavioral effects.
机译：具有 - 吡咯烷酮的理由作品（-PVP），第二代合成氨基酮，一般限于外消旋体。考虑到其他合成天然酮，它们的对映体之间存在行为和神经化学差异，差异也可以通过-PVP.Objectivesthe看到通过比较它们的能力来评估每个对映体对外消旋 - PVP的相对贡献诱导条件的味道避免。一切阳性雄性Sprague-Dawley大鼠每隔一天暴露于新的糖精溶液，然后立即注射0（盐水）或1.5,3或6mg / kg的S-，R - 或外消旋 - PVP（IP）。在交替的日子里，所有受试者都获得了水，以评估-PVP对一般流体消费的任何无条件效果。注射用外消旋酸盐和-PVP的S-异构体的避免药物相关的糖精溶液，尽管这种避免是仅适用于注入外消旋物的受试者。在任何测试的任何剂量的动物中，没有避免味道的味道避免。注射3mg / kg外消旋 - PVP的动物在避免的那些对S-对映体的避免避免的情况下没有差异，但用6mg / kg外消旋 - PVP处理的受试者比用3mg处理的避免显着更强的避免/ kg s - pvp.Conclusionsthe目前的工作表明外消旋-PVP的厌恶效果主要由其S-异构体介导。在最高剂量（6mg / kg）的情况下，外消旋物诱导避免大于S-和R-异构体的简单添加剂（3mg / kg）表明，虽然R-异构体可能不会诱导味道避免此剂量，它可以在介导外消旋混合物的效果中与S-异构体协同相互作用。这些结果是根据与许多精神疗法报告的其他行为和生理终点的类似效果讨论，并表明-PVP的对映体是表征其行为效应的重要变量。

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