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Scheduling synthetic cathinone substances under the Controlled Substances Act

机译：在受控物质作用下调度合成的显碱基物质

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Background and rationaleCathinones are amphetamine analogues that produce stimulant effects with rewarding properties. For many decades, synthetic cathinones have been used in the United States (USA) for abuse purposes, leading to concern about public safety by the federal government. Under the Controlled Substances Act (CSA), the federal government may place drugs with high abuse potential but no currently accepted medical use into Schedule I of the CSA. The process of scheduling an abusable drug involves both the Department of Health and Human Services (HHS), through the Food and Drug Administration (FDA) and the National Institute on Drug Abuse (NIDA), and the Department of Justice, through the Drug Enforcement Administration (DEA).ResultsThis paper details how numerous synthetic cathinones were placed under CSA control between 1973 and 2018, with an emphasis on 10 cathinones that were placed into Schedule I in 2017 (butylone, naphyrone, pentylone, pentedrone, 3-fluoro-N-methylcathinone (FMC), 4-FMC, 4-methyl-N-ethylcathinone, 4-methyl-pyrrolidinopropiophenone, alpha-pyrrolidinobutiophenone, and -pyrrolidinopentiophenone). A summary is provided of the scientific and medical analysis performed by HHS, in the form of an Eight-Factor Analysis (8FA), as prescribed by the CSA. This 8FA was then evaluated and signed by the Assistant Secretary for Health at HHS and transmitted to DEA, which permanently placed the 10 cathinones into Schedule I after public notices were published into the Federal Register.Discussion and conclusionsUnderstanding the scientific data, analysis, and complex process utilized by the US federal government in the CSA scheduling of cathinones with abuse potential and no accepted medical use is important for transparency in governmental decision-making.
机译：背景技术和律程质酮是制备兴奋剂的浓缩效果，具有奖励性能。多十年来，美国（美国）已用于滥用滥用目的的合成阴茎，导致联邦政府的公共安全担忧。根据“受控物质法”（CSA），联邦政府可能将滥用滥用潜力的药物，但目前尚未接受医疗用途进入CSA的附表I。安排滥用药物的过程涉及卫生和人类服务部（HHS），通过食品和药物管理局（FDA）和国家药物滥用行政管理（NIDA）和司法部，通过药物执法施用（DEA）.Resultstthis纸张详细介绍了1973年至2018年间CSA控制下的许多合成天然碱基，重点是2017年（丁基，萘酮，戊酮，浮子，3氟-N - 甲基肠酮（FMC），4-FMC，4-甲基-N-乙胱氨酸，4-甲基 - 吡咯烷丙酮，α-吡咯烷苯甲酮和吡咯烷酮酮）。由HHS进行的科学和医学分析提供了由CSA规定的八因素分析（8FA）的形式提供的科学和医学分析。然后，该8FA被助理HHS助理助理秘书签署并签署了DEA，该DEA将10个鸟瞰在公开通知书发表于联邦登记册之后，将10个视线纳入附表。和得出的科学数据，分析和复杂，分析美国联邦政府在CSA在CSA调度中使用滥用潜力和接受的医疗用途的过程对政府决策的透明度很重要。

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