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首页> 外文期刊>Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal >Examining bi-anodal transcranial direct current stimulation (tDCS) over bilateral dorsolateral prefrontal cortex coupled with bilateral extracephalic references as a treatment for negative symptoms in non-acute schizophrenia patients: A randomized, double-blind, sham-controlled trial
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Examining bi-anodal transcranial direct current stimulation (tDCS) over bilateral dorsolateral prefrontal cortex coupled with bilateral extracephalic references as a treatment for negative symptoms in non-acute schizophrenia patients: A randomized, double-blind, sham-controlled trial

机译：检查双侧背侧前额定皮层的双阳极经颅直流刺激（TDCS）与双侧肺部参考引用，作为非急性精神分裂症患者的阴性症状治疗：随机，双盲，假手术试验

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No studies have examined the efficacy of bi-anodal transcranial direct current stimulation (tDCS) over bilateral dorsolateral prefrontal cortex (DLPFC) coupled with bilateral extracephalic references in treating negative symptoms of non-acute schizophrenia patients. This study aimed to investigate the therapeutic effects of the new approach of tDCS on negative symptoms, other schizophrenia symptoms, cognitive deficits and psychosocial functioning in a double-blind, randomized, sham-controlled trial. Patients with non-acute schizophrenia (N = 60) in randomized order received sham treatment or bilaterally provided tDCS (2 mA, twice-daily sessions for five consecutive days) with the anode over the DLPFC and the reference (cathode) over the ipsilateral forearm. The negative symptoms as measured by a dimensional approach of Positive and Negative Syndrome Scale (PANSS) were rapidly reduced by bimodal tDCS relative to sham stimulation (F = 24.86, Cohen's d = 0.661, p = 6.11 x 10(-6)). The beneficial effect on negative symptoms lasted for up to 3 months. The authors also observed improvement with tDCS of psychosocial functioning as measured by the global score of Personal and Social Performance scale (PSP) and psychopathological symptoms especially for disorganization and cognitive symptoms as measured by the PANSS. No effects were observed on other schizophrenia symptom dimensions and the performance on a series of neurocognitive tests. Our results show promise for bi-anodal tDCS over bilateral DLPFC using bilateral extracephalic references in treating negative symptoms and other selected manifestations of schizophrenia. Further studies with electrophysiological or imaging evaluation help unravel the exact mechanism of action of this novel stimulation parameter of tDCS in schizophrenia patients.
机译：没有研究对双侧背面前额外皮层（DLPFC）相结合的双侧背面前额定皮层（DLPFC）的疗效检查了与双侧细胞段引用治疗非急性精神分裂症患者的阴性症状。本研究旨在探讨TDCS对阴道，随机的，假手动试验中的对抗阴性症状，其他精神分裂症症状，认知缺陷和心理社会功能的治疗效果。随机顺序中的非急性精神分裂症（n = 60）的患者接受假治疗或双侧提供TDC（连续5天两次，每次两次），在DLPFC上通过IPsilAtalal Forearm的参考（阴极） 。通过双模TDCs相对于假刺激迅速降低了通过尺寸和阴性综合征尺度（平底锅）的尺寸方法测量的阴性症状（F = 24.86，COHEN的D = 0.661，P = 6.11×10（-6））。对阴性症状的有益效果持续长达3个月。作者还观察到通过全球个人和社会绩效规模（PSP）和精神病理学症状的全球成绩来改善心理社会功能的改善，特别是由平底锅测量的紊乱和认知症状。在其他精神分裂症症状尺寸和一系列神经认知测试中没有观察到任何影响。我们的结果表明，双边DLPFC使用双侧含有双侧细胞段治疗消极症状和其他精神分裂症的表现形式的Bi-Anodal TDC。进一步的电生理学或影像学评估研究有助于解开精神分裂症患者TDC的这种新型刺激参数的确切作用机制。

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