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首页> 外文期刊>Pulmonary pharmacology & therapeutics >Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury
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Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury

机译：在暴露于卷烟烟雾期间的哌盂隆的影响可减少炎症和肺损伤

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Chronic obstructive pulmonary disease (COPD) is related to smoking and anti-inflammatory therapy is indicated. Among the mediators with anti-inflammatory properties, we highlight piperlongumine (PL), an alkaloid/amide of Piper longum. Here we evaluated the PL administration on an experimental model of respiratory inflammation resulting from exposure to cigarette smoke. Male Balb/c mice were exposed to burning of 10 commercial cigarettes, 2x/day, for five weeks on specific equipment. PL efficacy was evaluated in control, exposed to smoke without treatment and PL treated (2.0 mg/kg, 3x/week) groups. Animals were weighed and plethysmographic analyses performed at the end of the exposure protocol. Inflammatory cells were evaluated in the bronchoalveolar lavage (BAL) and hemoglobin and glucose in the blood. Lung fragments were processed for histopathological studies and AnxA1, COX-2, NF-kB and neutrophil elastase expressions. Plethysmography revealed that PL maintained pulmonary frequency, volume and ventilation parameters similar to controls, with respiratory volume reduction compared to untreated animals. Final weight was reduced in both exposed groups. PL decreased hemoglobin concentration, attenuated the reduction of glucose levels and reduced influx of lymphocytes, neutrophils and macrophages in BAL. Histopathologically occured infiltration of inflammatory cells, increase of the interalveolar septa and intra-alveolar spaces in untreated animals. But, PL administration recovered lung tissues and, immunohistochemically, promoted increased expression of AnxA1 and reduction of COX-2, NF-kB and neutrophil elastase. Together the results indicate that PL attenuates systemic and pulmonary inflammatory changes, partially by modulating the expression the endogenous AnxA1, and may represent a promising therapy in preventing the inflammation induced by cigarette smoke.
机译：慢性阻塞性肺病（COPD）与吸烟有关，并指出抗炎治疗。在具有抗炎性质的介质中，我们突出了哌隆（PL），一种吹笛剂浪环的生物碱/酰胺。在这里，我们评估了PL给予呼吸炎症的实验模型，由卷烟烟雾引起的呼吸炎症。雄性BALB / C小鼠暴露于10个商用香烟，2次/天，在特定设备上五周的燃烧。在对照中评估PL功效，暴露于烟雾而无需治疗，并且PL处理（2.0mg / kg，3x /周）组。称量动物并在暴露方案结束时进行体积分析。在支气管肺泡灌洗（BAL）和血红蛋白中评估炎症细胞和血液中的血糖。对组织病理学研究和ANXA1，COX-2，NF-KB和中性粒细胞弹性蛋白酶表达进行肺片段。体积描记揭示了PL维持肺频率，容量和通风参数，类似于对照，与未经处理的动物相比，呼吸体积减少。两种暴露组中的最终重量减少。 PL降低血红蛋白浓度，减轻葡萄糖水平的减少，降低淋巴细胞涌入，中性粒细胞和巨噬细胞在BAL中。组织病理学发生炎症细胞的渗透，在未处理的动物中增加室内静脉和肺泡空间。但是，PL给药回收肺组织，免疫组织化学，促进了ANXA1的表达和COX-2，NF-KB和中性粒细胞弹性蛋白酶的增加。结果表明，通过调节内源性ANXA1的表达，PL可以衰减全身和肺炎炎症变化，并且可以代表预防香烟烟雾诱导的炎症的有希望的治疗。

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