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首页> 外文期刊>Quintessence international >Effect on wound healing of a topical gel containing amino acid and sodium hyaluronate applied to the alveolar socket after mandibular third molar extraction: A double-blind randomized controlled trial
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Effect on wound healing of a topical gel containing amino acid and sodium hyaluronate applied to the alveolar socket after mandibular third molar extraction: A double-blind randomized controlled trial

机译：含有氨基酸含氨基酸和透明质酸钠的突起愈合效果在下颌第三磨牙萃取后施用于肺泡插座：双盲随机对照试验

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Objective: The study aimed to assess the effect of topical applications of an amino acid and sodium hyaluronate gel after mandibular third molar extraction. Method and Materials: 136 patients requiring mandibular third molar extraction were enrolled. An amino acid and sodium hyaluronate gel was applied to the sockets of patients in the test group immediately following the extraction. The sockets of controls were simply flushed with a sterile saline solution. Patients' outcomes and postoperative complications were assessed 7 and 14 days after surgery. The cumulative incidence of dehiscence and secondary outcome measures were analyzed using a chi-square test. Results: Concerning the primary outcome, the incidence of dehiscence was 27.4% after 7 days in the treatment group and 36.4% in the controls (P =.28), and at 14 days it was 21.4% and 36.0%, respectively (P =.10). No statistically significant differences emerged in other variables (mouth opening range, appearance of soft tissue, presence of pus, pain on palpation of the alveolar socket, alveolitis, local lymphadenopathy, and adverse reactions). Pain perception was always lower in the treatment group during the first 7 days after surgery. Conclusion: Topical applications of an amino acid and sodium hyaluronate gel after mandibular third molar extraction made no statistically significant difference to the variables examined in the test and control groups. Clinical Relevance: This trial focused on postoperative complications after surgical third molar extraction. The use of a gel containing amino acid and sodium hyaluronate was investigated for the management of post operative pain, edema, alveolitis, wound dehiscence and swelling.
机译：目的：该研究旨在评估氨基酸和透明质酸钠凝胶后颌骨三摩尔萃取后的局部应用的影响。方法和材料：注册了136名需要下颌第三摩尔提取的患者。在提取后立即将氨基酸和透明质酸钠凝胶应用于试验组中的患者的插座。用无菌盐水溶液冲洗控制插座。患者的结果和术后并发症在手术后7和14天评估。使用Chi-Square试验分析了累积裂开和次要结果措施的累积发病率。结果：关于主要结果，治疗组7天后裂开的发生率为27.4％，对照组36.4％（P = .28），分别为21.4％和36.0％（P = .10）。在其他变量中没有出现统计学上显着的差异（口开口范围，软组织的外观，脓液的存在，肺泡瓣触觉的疼痛，牙槽炎，局部淋巴结病和不良反应）。在手术后的前7天内治疗组疼痛感知始终较低。结论：颌骨第三摩尔萃取后氨基酸和透明质酸钠凝胶的局部应用对试验和对照组中检测的变量没有统计学显着差异。临床相关性：该试验专注于手术三摩尔提取后的术后并发症。研究了使用含有氨基酸和透明质酸钠的凝胶，用于治疗术后疼痛，水肿，肺炎，伤口裂开和肿胀。

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