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首页> 外文期刊>Psychiatry research >Evening preference and poor sleep independently affect attentional-executive functions in patients with depression
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Evening preference and poor sleep independently affect attentional-executive functions in patients with depression

机译：晚间偏好和贫困睡眠独立影响抑郁症患者的注意力 - 行政功能

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Cognitive impairments are well documented in major depressive disorder (MDD), however, they cannot be fully explained by depressive symptom severity. We investigated how diurnal preference and sleep quality affect cognitive function in MDD. In 34 inpatients with current MDD and 29 healthy controls (HC), we obtained diurnal preference (Momingness-Eveningness Questionnaire, MEQ) and subjective sleep quality (Pittsburgh Sleep Quality Index, PSQI). Further, current mood and neuropsychological performance (Trail Making Test, TMT, part A and B) were assessed in the evening and in the following morning. Patients with MDD performed worse than HC on the TMT-B (particularly requiring executive function), but not on the TMT-A (assessing foremost visuomotor processing speed). In general, participants with evening preference (MEQ-score median split) performed poorer on the TMT than participants with morning preference. Subgroup analyses within MDD confirmed the negative effect of evening preference on the TMT. In addition, patients with severely impaired sleep quality (PSQI > 10) performed cognitively worse than patients with normal to moderately impaired sleep quality (PSQI <= 10). The results were largely independent of current mood state. Our findings suggest that evening preference and severely impaired sleep quality independently contribute to cognitive impairment in MDD.
机译：认知障碍在重大抑郁症（MDD）中良好记录，但是，不能通过抑郁症状严重性充分解释它们。我们调查了昼夜偏好和睡眠质量如何影响MDD中的认知功能。在34例内部有MDD和29种健康对照（HC）的住院患者中，我们获得了昼夜偏好（Momingness-Deventness Consputnaire，MEQ）和主观睡眠质量（Pittsburgh睡眠质量指数，PSQI）。此外，在晚上和第二天早晨评估当前的情绪和神经心理学性能（TRAIL制作测试，TMT，A和B）。 MDD的患者在TMT-B（特别需要执行功能）上表现比HC更差，但不是在TMT-A（评估最重要的求核对处理速度）上。一般来说，晚间偏好的参与者（MEQ-Score Median Split）比早晨偏好的参与者在TMT上表现较差。 MDD中的亚组分析证实了晚间偏好对TMT的负面影响。此外，睡眠质量严重受损的患者（psqi> 10）的患者表现比睡眠质量正常（psqi <= 10）正常的患者表现差。结果在很大程度上与当前的情绪状态无关。我们的研究结果表明，晚间偏好和严重受损的睡眠质量独立促进MDD中的认知障碍。

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