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首页> 外文期刊>Psychiatry Research. Neuroimaging >Resting-state functional connectivity in medication-naive adolescents with major depressive disorder
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Resting-state functional connectivity in medication-naive adolescents with major depressive disorder

机译：休息状态在药物 - 天真青少年中的功能连通性，具有重大抑郁症

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摘要

Adolescence is a vulnerable period for major depressive disorder (MDD). The aim of our study was to investigate resting-state functional connectivity (RSFC) in first-episode, medication-naive adolescent MDD patients. Twenty-three drug-naive adolescents diagnosed with first-episode MDD and 27 healthy participants were enrolled. Seedto-voxel RSFC analyses were performed. The frontolimbic circuit regions of interest included the amygdala, anterior cingulate cortex, insula, and hippocampus. A correlation analysis between the RSFC and Children's Depression Inventory, Hamilton depression rating scale, and duration of episodes was performed. The adolescents with MDD exhibited the following characteristics: a lower RSFC between the right amygdala and right superior frontal gyrus; a lower RSFC between the right hippocampus and clusters including the right insula and right middle frontal gyrus; a higher RSFC between the left insula and clusters including the bilateral middle frontal gyrus, right superior frontal gyrus, and right frontal pole; and a higher RSFC between the left dorsal anterior cingulate cortex and a cluster including the left insula. Medication-naive adolescents with depression display lower connectivity of several brain regions implicated in processing, regulation, and memory of emotions. Higher connectivity was observed in brain regions that potentially explain rumination, impaired concentration, and physiological arousal.
机译：青春期是主要抑郁症（MDD）的脆弱期。我们的研究目的是在一发集，药物 - 天真青少年MDD患者中调查休息状态功能连接（RSFC）。注册了二十三只诊断出第一集发作MDD和27名健康参与者的毒药天真青少年。进行SeedTo-Voxel RSFC分析。寄生虫电路区域包括Amygdala，前刺铰霉型皮质，Insula和海马。进行了RSFC和儿童抑郁库存，汉密尔顿抑制评级规模和剧集持续时间的相关分析。具有MDD的青少年表现出以下特点：右杏仁右侧和右高级环之间的较低的RSFC;在右海马和群集之间的较低的RSFC，包括右侧Insula和右中正面回值;左侧内侧和簇之间的较高RSFC，包括双侧中正面回射，右高额相回到和右前杆;左背侧铰接皮质和包括左侧insula的簇之间的更高RSFC。药物 - 天真的青少年具有抑郁症的几个脑区的连接率涉及加工，调节和情绪记忆。在脑区观察到较高的连接，潜在地解释谣言，浓度受损和生理唤醒。

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