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首页> 外文期刊>Psychiatry Research. Neuroimaging >Pineal gland abnormality in major depressive disorder
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Pineal gland abnormality in major depressive disorder

机译：针刺腺体异常在重大抑郁症

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Patients with major depressive disorder (MDD) often have circadian rhythm alteration and sleep disturbance. The pineal gland regulates the circadian rhythm and sleep by the secretion of melatonin neurohormone. However, the relationship between pineal abnormality and MDD remains elusive. 50 patients with MDD and 35 gender- and age-matched healthy controls underwent high-resolution structural MRI. Pineal parenchymal volume (PPV) was measured manually. Inter-group differences in prevalence of pineal cyst and PPV were examined. In addition, we investigated the correlations between PPV and symptom severity as well as sleep variables in the patient group. Compared to healthy controls, patients with MDD had a higher prevalence of pineal cyst. Moreover, patients had significantly decreased PPV relative to controls. However, no significant correlations were observed between PPV and symptom severity as well as sleep variables. Our findings suggest that pineal abnormality may play a critical role in depression.
机译：患有主要抑郁症（MDD）的患者经常具有昼夜节律改变和睡眠障碍。松果腺体通过褪黑激素神经核糖核酸的分泌来调节昼夜节律和睡眠。然而，松果异常与MDD之间的关系仍然难以捉摸。 50例MDD和35例性别和年龄匹配的健康对照接受高分辨率结构MRI。针状实体体积（PPV）手动测量。检查了针孔囊肿和PPV的普遍率的组间差异。此外，我们研究了PPV和症状严重程度与患者组中的睡眠变量之间的相关性。与健康对照相比，MDD患者对松果囊肿的患病率较高。此外，患者相对于对照的PPV显着降低。然而，在PPV和症状严重程度以及睡眠变量之间没有观察到显着相关性。我们的研究结果表明，松果异常可能在抑郁症中发挥着关键作用。

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