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首页> 外文期刊>Psychiatry Research. Neuroimaging >Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy
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Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy

机译：使用磁共振光谱抑制谷氨酸和神经功能障碍

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Although postpartum depression (PPD) is a prevalent subtype of major depressive disorder, neuroimaging studies on PPD are rare, particularly those identifying neurochemical abnormalities obtained by proton magnetic resonance spectroscopy (H-1-MRS). The dorsolateral prefrontal (DLPF) and the anterior cingulate gyrus (ACG) are part of the neural pathways involved in executive functions and emotional processing, and both structures have been implicated in the neurobiology of depressive disorders. This study aimed to evaluate brain metabolites abnormalities in women with PPD compared with healthy postpartum (HP) women. Thirty-six PPD (34 without antidepressants) and 25 HP women underwent a H-1-MRS acquired on a 3-T MRI system, with the volume of interest positioned in ACG and DLPF. An ANCOVA was conducted with age, postpartum time, and contraceptive type as covariates. PPD group presented significantly lower Glutamate + Glutamine (Glx, -0.95 mM) and N-acetylaspartate + N-acetylaspartylglutamate (NAA, -0.60 mM) values in DLPF. There were no significant differences between groups in ACG, but we found a significant increase of Glutamate (Glu, 2.18 mM) and Glx (1.84 mM) in participants using progestogen-only contraceptives. These findings suggest glutamatergic dysfunction and neuronal damage in the DLPF of PPD patients, similarly to other subtypes of depressive disorders. Progestogens seem to interfere in the neurochemistry of ACG.
机译：虽然产后抑郁症（PPD）是主要抑郁症的普遍存在亚型，但PPD的神经影像学研究罕见，特别是那些鉴定通过质子磁共振光谱（H-1-1-MRS）获得的神经化学异常的亚型。背侧前额外（DLPF）和前铰接回物（ACG）是执行功能和情绪处理中所涉及的神经途径的一部分，并且两种结构都涉及抑郁症的神经生物学。该研究旨在评估与健康产后（HP）妇女的PPD妇女的脑代谢物异常。三十六个PPD（34号抗抑郁药）和25人妇女接受了在3-T MRI系统上获得的H-1-MRS，其利率体积定位在ACG和DLPF中。 Ancova是随着协变者的年龄，产后时间和避孕型进行的。 PPD组在DLPF中呈现显着降低谷氨酸+谷氨酰胺（GLX，-0.95mm）和N-乙酰刺酸盐+ N-乙酰吡咯烷醇（NAA，-0.60mm）值。 ACG的群体之间没有显着差异，但我们发现使用孕激素避孕药的参与者谷氨酸（Glu，2.18mm）和Glx（1.84 mm）的显着增加。这些研究结果表明PPD患者DLPF中的谷氨酸宫功能障碍和神经元损伤，类似于抑郁症的其他亚型。孕激素似乎干扰了ACG的神经化学。

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