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首页> 外文期刊>Psychiatry Research. Neuroimaging >Switching between internally and externally focused attention in obsessive-compulsive disorder: Abnormal visual cortex activation and connectivity
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Switching between internally and externally focused attention in obsessive-compulsive disorder: Abnormal visual cortex activation and connectivity

机译：在强迫症的内部和外部重点关注之间切换：异常的视觉皮质激活和连接

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摘要

Obsessive-compulsive disorder (OCD) is characterized by excessive absorption with internally-generated distressing thoughts and urges, with difficulty incorporating external information running counter to their fears and concerns. In the present study, we experimentally probed this core feature of OCD through the use of a novel attention switching task that investigates transitions between internally focused (IF) and externally focused (EF) attentional states. Eighteen OCD patients and 18 controls imagined positive and negative personal event scenarios (IF state) or performed a color-word Stroop task (EF state). The IF/EF states were followed by a target detection (TD) task requiring responses to external stimuli. Compared to controls, OCD patients made significantly more errors and showed reduced activation of superior and inferior occipital cortex, thalamus, and putamen during TD following negative IF, with the inferior occipital hypoactivation being significantly greater for TD following negative IF compared to TD following the other conditions. Patients showed stronger functional connectivity between the inferior occipital region and dorsomedial prefrontal cortex. These findings point to an OCD-related impairment in the visual processing of external stimuli specifically when they follow a period of negative internal focus, and suggest that future treatments may wish to target the transition between attentional states.
机译：强迫症（OCD）的特点是过度吸收与内部产生的令人痛苦的思想和敦促，难以将外部信息纳入他们的恐惧和担忧。在本研究中，我们通过使用新的注意力切换任务来通过使用内部聚焦（IF）和外部聚焦（EF）注意力（EF）注意力态之间的转换来实验探讨了OCD的这种核心特征。十八名OCD患者和18个控制器想象的正面和负数个人事件情景（如果状态）或进行颜色字链条任务（EF状态）。 IF / EF状态后面是需要对外部刺激响应的目标检测（TD）任务。与对照组相比，OCD患者的误差显着增加，并且在TD期间，在负接下来的情况下，在TD之后，TD在TD期间，对于在另一个之后的TD相比，TD的秋季性胃癌显着更大状况。患者在下枕区和背侧前额外皮层之间表现出更强的功能连通性。这些发现指出了对外部刺激的视觉处理的OCD相关的损伤，特别是当他们遵循一个负面的内部重点时，建议未来的治疗可能希望瞄准注意力状态之间的过渡。

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