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Face and gaze perception in borderline personality disorder: An electrical neuroimaging study

机译：边缘人格障碍的面部和凝视感知：电气神经影像学研究

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Abstract Humans are sensitive to gaze direction from early life, and gaze has social and affective values. Borderline personality disorder (BPD) is a clinical condition characterized by emotional dysregulation and enhanced sensitivity to affective and social cues. In this study we wanted to investigate the temporal-spatial dynamics of spontaneous gaze processing in BPD. We used a 2-back-working-memory task, in which neutral faces with direct and averted gaze were presented. Gaze was used as an emotional modulator of event-related-potentials to faces. High density EEG data were acquired in 19 females with BPD and 19 healthy women, and analyzed with a spatio-temporal microstates analysis approach. Independently of gaze direction, BPD patients showed altered N170 and P200 topographies for neutral faces. Source localization revealed that the anterior cingulate and other prefrontal regions were abnormally activated during the N170 component related to face encoding, while middle temporal deactivations were observed during the P200 component. Post-task affective ratings showed that BPD patients had difficulty to disambiguate neutral gaze. This study provides first evidence for an early neural bias toward neutral faces in BPD independent of gaze direction and also suggests the importance of considering basic aspects of social cognition in identifying biological risk factors of BPD. Highlights ? This study provides evidence for an early neural bias toward neutral faces in BPD. ? BPD patients showed altered N170 and P200 topographies for neutral faces. ? The anterior cingulate was abnormally activated during the N170 component. ? BPD patients had difficulty to disambiguate neutral gaze.
机译：摘要人类对早期生命的凝视方向敏感，凝视具有社会和情感价值。边界人格障碍（BPD）是一种临床状况，其特征在于情绪化失调，增强对情感和社会提示的敏感性。在这项研究中，我们希望研究BPD中自发凝视处理的时间空间动态。我们使用了一个2后工作记忆的任务，其中提出了具有直接和避免凝视的中性面。凝视被用作面向事件相关电位的情绪调制器。高密度EEG数据在19名女性与BPD和19名健康女性中获得，并分析了一种时空微肥小分析方法。独立于凝视方向，BPD患者显示出变化的N170和P200的中性面的地形。源定位显示，在与面部编码有关的N170组分期间，在与面部编码有关的N170组分期间异常激活前铰接和其他前序区域，而在P200组分期间观察到中间时间去激活。任务后的情感评级表明，BPD患者难以消除中性凝视。本研究提供了第一证据表明早期神经偏向于独立于凝视方向的BPD中的中性面，并且还表明在识别BPD的生物危险因素时考虑社会认知的基本方面的重要性。强调 ？本研究提供了对BPD中型脸部的早期神经偏见的证据。还BPD患者显示出中性面的N170和P200地形改变。还在N170组分期间异常激活前铰接。还BPD患者难以消除中性凝视。

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