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首页> 外文期刊>Psychiatry Research. Neuroimaging >Comparing abnormalities of amplitude of low-frequency fluctuations in multiple system atrophy and idiopathic Parkinson's disease measured with resting-state fMRI
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Comparing abnormalities of amplitude of low-frequency fluctuations in multiple system atrophy and idiopathic Parkinson's disease measured with resting-state fMRI

机译：用休息状态FMRI测量多种系统萎缩和特发性帕金森病的低频波动幅度异常

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Abstract Multiple system atrophy (MSA) and Idiopathic Parkinson's disease (IPD) show overlapping clinical manifestations with different treatment and prognosis. However, the shared and distinct underlying neural substrates are not yet understood, which needs to be explored between MSA and IPD. Resting-state functional magnetic resonance imaging data were collected from 29 MSA patients, 17 IPD patients and 25 healthy controls (HC) and the Amplitude of Low-Frequency Fluctuations (ALFF) was compared. Lower ALFF in bilateral basal ganglion, bilateral ventrolateral prefrontal cortex and right amygdala, as well as higher ALFF in parieto-temporo-occipital cortex and right cerebellum was shared between both patient groups to compare with HC. In contrast to IPD, decreased or increased ALFF in different regions of visual associative cortices and decreased ALFF in right cerebellum were found in MSA group. Our findings suggested shared and distinct spontaneous brain activity abnormalities in striato–thalamo-cortical (STC) loop, default mood network, visual associative cortices and cerebellum were present in MSA and IPD, which may help to explain similar clinical symptoms in both disorders but a more severe illness prognosis in MSA. Further research is needed to better describe the functional role of the cerebellum and visual associative cortices in early stages of MSA and IPD.
机译：摘要多种系统萎缩（MSA）和特发性帕金森病（IPD）显示出具有不同治疗和预后的重叠临床表现。然而，尚未理解共享和不同的潜在的神经基材，这需要在MSA和IPD之间探索。从29例MSA患者收集休息状态功能磁共振成像数据，17名IPD患者和25例健康对照（HC）和低频波动（ALFF）的幅度进行了比较。双侧基底神经节的较低的ALFF，双侧腹外侧前额定皮层和右杏仁醛，以及在两种患者组之间共用了Parieto-Temporto-Temporto-Temporital皮质皮质和右脑杆菌的较高ALFF。与HC进行比较。与IPD相比，在视觉联想皮质的不同地区下降或增加了ALFF，并在MSA组中发现了右小脑中的ALFF。我们的研究结果提出了STRIATO-Thalamo-Cortical（STC）循环的共同和不同的自发性脑活动异常，默认情绪网络，Visual Associative Portices和Cerebellum存在于MSA和IPD中，这可能有助于在两种疾病中解释类似的临床症状但是MSA中更严重的疾病预后。需要进一步的研究以更好地描述小脑和视觉联想皮质在MSA和IPD的早期阶段的功能作用。

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