• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Individual OCD-provoking stimuli activate disorder-related and self-related neuronal networks in fMRI
【24h】

Individual OCD-provoking stimuli activate disorder-related and self-related neuronal networks in fMRI

机译：个人强大的刺激刺激激活FMRI中的紊乱相关和自相关神经元网络

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

For patients with Obsessive-Compulsive Disorder (OCD), whose triggers are highly idiosyncratic, individual stimulus material has been used in several fMRI studies. This study aims at comparing individual to standardized picture sets and at investigating a possible overlap of the former with the self-referential neuronal network. During fMRI-scanning, 17 inpatients with OCD and 17 healthy controls were exposed to pictures of their personal triggers, photographed in their domestic environments, to standardized pictures designed to provoke OCD symptoms, and to neutral pictures. Whole-brain analyses were calculated and the pictures were rated by both patients and controls with respect to valence, arousal, and coping. Patients rated the individualized stimuli lower in valence and coping and higher in arousal compared to controls, and also compared to standardized OCD - and neutral stimuli. The individual stimuli elicited neuronal activity in the cingulate cortex, hippocampus, insula, middle frontal/precentral gyrus, superior/inferior parietal lobe, and precuneus, while no group difference was detected by the standardized OCD-stimuli. In conclusion, individual picture sets facilitate the detection of neuronal activity, but the results might be confounded due to the overlap with the network of self-referential processing and memory retrieval. The use of individual symptom-provoking and individual neutral stimuli would therefore be optimal.
机译：对于具有强迫症（OCD）的患者，其触发器是高度特质的，在几种FMRI研究中已经使用了个体刺激材料。本研究旨在将个体与标准化的图像集进行比较，并在研究前者与自引导神经元网络的可能重叠。在FMRI扫描期间，17名具有OCD和17个健康对照的住院患者接触到他们在国内环境中拍摄的个人触发器的图片，以旨在挑衅OCD症状，并向中性图片攻击标准的照片。计算全脑分析，并通过患者，对价，唤起和应对的控制评定。与对照相比，患者在唤醒和唤醒中较低的个体化刺激，较高，也与标准化的OCD和中性刺激相比。单独的刺激引发神经元活性在Cingulate Cortex，海马，insula，中正程/前列rus，优质/劣质凸角和前血管中，而标准化的OCD-Simuli检测到NO组差异。总之，个体图像集有助于检测神经元活动，但由于与自信处理和存储器检索的网络重叠，结果可能会被混淆。因此，使用个人症状激发和个人中性刺激将是最佳的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号