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Structural, functional, and neurochemical neuroimaging of methamphetamine-associated psychosis: A systematic review

机译：甲基苯丙胺相关精神病的结构，功能和神经化学神经模仿：系统审查

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摘要

Methamphetamine is a highly addictive psychostimulant. A subset of methamphetamine users develops methamphetamine-associated psychosis (MAP), which causes poorer prognoses and cognitive function than those with no psychosis (MNP). Comprehensive and integrative summaries of studies utilizing various neuroimaging modalities (structural, functional, and neurochemical) are limited. We conducted a systematic review of literature regarding clinical neuroimaging research published between January 1988 and July 2018 using the PubMed, Web of Science, Scopus, and ScienceDirect databases. Studies comparing the neuroimaging of patients with MAP with healthy controls or patients with MNP or schizophrenia were included to understand the distinct profiles associated with MAP. A total of six structural, three functional, and three neurochemical studies were reviewed. A general trend was identified that showed MAP-related brain alterations were mainly in the frontal lobe (especially the orbitofrontal cortex), striatum, and limbic systems (amygdala and hippocampus). Furthermore, some clinical manifestations, such as the severity of psychotic symptoms and cognitive performance, were correlated with neuroimaging abnormalities. In summary, distinct structural, functional, and neurochemical changes, especially in the frontostriatal circuit and network dynamic systems, play critical roles in the pathophysiology of MAP. Future studies using longitudinal study designs and including individuals with MNP and schizophrenia as controls are warranted.
机译：甲基苯丙胺是一种高度上瘾的精神疗法。甲基苯丙胺用户的子集发育甲基苯丙胺相关的精神病（MAP），其导致比没有精神病（MNP）的较差的预期和认知功能。利用各种神经影像样机（结构，功能和神经化学）的综合和综合研究。我们对2018年1月至2018年1月至2018年7月期间发布的临床神经影像学研究的文献进行了系统审查，使用PubMed，Scopus和ScienceActect数据库。将与健康对照或患有MNP或精神分裂症患者的地图患者的患者的神经模仿的研究以了解与地图相关的明显曲线。综述了总共六项结构，三种功能和三项神经化学研究。确定了一般趋势，显示与地图相关的脑改变主要是额叶（尤其是眶内皮质），纹状体和肢体系统（Amygdala和海马）。此外，一些临床表现，例如精神病症状和认知性能的严重程度与神经影像异常异常相关。总之，不同的结构，功能和神经化学变化，尤其是在前端电路和网络动态系统中，在地图的病理生理学中起重要作用。有必要使用纵向研究设计的未来研究，包括具有MNP和精神分裂症作为控制的个体。

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