• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Aberrant fronto-striatal connectivity and fine motor function in schizophrenia
【24h】

Aberrant fronto-striatal connectivity and fine motor function in schizophrenia

机译：精神分裂症中异常的前纹状连接和精细电机功能

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abnormal fine motor function is a frequent finding in schizophrenia and has been linked to structural and functional brain alterations. However, whether fine motor function is related to functional alterations within the motor system remains unclear. The aim of this study was to assess whether abnormalities in resting-state functional connectivity are present in schizophrenia patients and to investigate how these abnormalities may be related to fine motor function. We examined 19 schizophrenia patients and 16 healthy controls using resting-state functional connectivity for 11 bilateral regions of interest. Fine motor function was assessed on a set of copying tasks and the Symbol-Digit-Substitution Test. We found significantly reduced functional connectivity between the left caudate nucleus and bilateral dorsolateral prefrontal cortex (DLPFC) and between the left putamen and bilateral supplementary motor area (SMA) proper in patients compared to controls. Altered connectivity from DLPFC to caudate nucleus was related to fine motor tasks, which are sensitive to psychomotor speed, whereas aberrant connectivity between the SMA proper and putamen was associated to both, fine motor task, which are sensitive to psychomotor speed and to speed of information processing. Our findings emphasize the role of fronto-striatal connections in the pathogenesis of fine motor impairments in schizophrenia.
机译：异常细小的电机功能是精神分裂症的频繁发现，并与结构和功能性大脑改变相关联。然而，固定电机功能是否与电动机系统内的功能改变有关。本研究的目的是评估精神分裂症患者的休息状态功能性的异常是否存在于精神分裂症患者中，并研究这些异常如何与细动电机功能有关。我们检查了19名精神分裂症患者和16名健康对照，用于11个双边地区的休息状态函数连通性。在一组复制任务和符号数字替换测试上评估了精细电机功能。与对照组相比，我们发现左尾骨核和双侧背侧前额定皮层（DLPFC）和双侧补充电动机面积（SMA）之间的左侧腐库和双侧补充电机面积（SMA）之间的功能连通性显着降低。从DLPFC到尾部的改变连接与精神电机速度敏感的精细电机任务有关，而SMA适当和PUTAMEN之间的异常连通性与精致的电机任务都与精神电机速度敏感并提供信息加工。我们的调查结果强调了前纹身联系在精神分裂症中的精细电机损伤发病机制中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号