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首页> 外文期刊>Psychiatry Research. Neuroimaging >Circuit activity underlying a distinct modulator of prepulse inhibition
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Circuit activity underlying a distinct modulator of prepulse inhibition

机译：潜在调制的电路活性抑制作用

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Prepulse inhibition (PPI), the diminished eye blink response to a startling pulse induced by a prepulse, is regulated by brainstem, and modulated by cerebral, processes. Attentional modulation by the prepulse (AMP), a potential biomarker of psychotic disorders, differs from other modulatory processes because it only occurs if the interval between the prepulse and pulse exceeds 100 ms (>PP100). Videotaped eye blinks were measured during fMRI scanning in 15 healthy subjects hearing 64 pulse alone, 64 PP60 and 64 PP120 trials in a rapid event-related design. Because attentional influences on PPI vary spontaneously, we posited AMP could be isolated by comparing eye blink and Blood Oxygen Level Dependent covariation during the two PP trial types. Behavioral regressor coefficients reflecting significant covariation covered the insula and auditory cortices during PP120 but not PP60 trials. Clusters within the right anterior insula and auditory cortex were specific to AMP. Functional connections (FCs) between cerebral ROIs implicated in PPI were stronger during PP120 trials. The four FCs that were individually stronger during PP120 trials involved the right insula or auditory cortex and three were not present during PP60 trials. Converging evidence indicates the right insula is the hub of a network underlying AMP.
机译：预先抑制（PPI），对由妊娠诱导的令人震惊的脉冲的减少的眼睛眨眼响应脑干调节，并通过脑，过程调节。 Prepulse（AMP）的预付调制，精神病疾病的潜在生物标志物，不同于其他调制过程，因为它仅发生在PrepulleS和脉冲之间的间隔超过100ms（> PP100之间）。在FMRI扫描期间在15个健康受试者中听到64个脉冲，64 PP60和64 PP120试验在快速事件相关的设计中，测量录像带眨眼。由于对PPI对PPI的注意力自发地变化，因此通过比较两种PP试验类型期间的眼睛眨眼和血氧水平依赖性协变量可以分离我们的放大器。在PP120期间，反映显着的协变的行为回归系数覆盖了Insula和听觉皮质，但不是PP60试验。右前肠内和听觉皮质内的簇特异于放大器。在PP120试验期间，在PPI中涉及PPI的脑罗尼斯之间的功能连接（FCS）在PPI期间较强。在PP120试验期间单独更强大的四种FC涉及右侧肠道或听觉皮层，第60次试验期间不存在三个。融合证据表明右侧Insula是网络底层AMP的集线器。

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