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首页> 外文期刊>Psycho-Oncology: Journal of the Psychological Social and Behavioral Dimensions of Cancer >Pro‐ and anti‐inflammatory cytokine associations with major depression in cancer patients
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Pro‐ and anti‐inflammatory cytokine associations with major depression in cancer patients

机译：具有癌症患者的主要抑郁症的促炎和炎症细胞因子关联

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Abstract Objective Cytokines may be linked to depression, although it has been challenging to demonstrate this association in cancer because of the overlap between depressive symptoms and other sickness behaviors. This study investigates the relationship between cytokines and depression in cancer patients, accounting for confounding clinical and methodological factors. Methods The GRID Hamilton Rating Scale for Depression and Neurotoxicity Rating Scale (NRS) for cytokine‐induced sickness behaviors were administered to 61 cancer patients and 38 healthy controls. The cancer group was of mixed type and largely of late stage, with a recruitment rate of 35% and completion rate of 47%. Major depression was diagnosed in 19 of 61 (31%) cancer patients. Multiplexed cytokine assays for inflammatory and anti‐inflammatory cytokines were conducted in plasma samples using electrochemiluminescence. Results All cancer patients had high NRS scores and elevated levels of most cytokines. Cancer patients with major depression had higher NRS scores than those without major depression. IL‐1rα was positively associated with the GRID scores of depressive symptoms (regression coefficient, 3.52?±?1.18; P ?=?.004), but not with major depression. Major depression was negatively associated with the anti‐inflammatory cytokine IL‐4 (regression coefficient, ?0.65?±?0.26; P ?=?.013), but not with IL‐1rα. Conclusions Depressive symptoms in cancer patients may represent sickness behaviors, which may have distinct cytokine associations from major depression. Sickness behaviors may be associated with an increase in inflammatory cytokines, whereas major depression may be induced by a failure to adequately resolve inflammation. Our findings suggest that cytokine‐mediated interventions may be of value to treat depression in this population.
机译：摘要目的细胞因子可能与抑郁症有关，尽管由于抑郁症状和其他疾病行为之间的重叠而致力于癌症中的这种关联是挑战性的。本研究研究了癌症患者细胞因子和抑郁症之间的关系，占混淆临床和方法论因素。方法对抑郁症和神经毒性评级规模（NRS）进行细胞因子诱导的疾病行为的Grid Hamilton评级规模施用至61例癌症患者和38例健康对照。癌症组是混合式，主要是晚期，招生率为35％，完井率为47％。主要抑郁症于61名（31％）癌症患者的19名中诊断出来。使用电化学发光在血浆样品中进行炎症和抗炎细胞因子的多重细胞因子测定。结果所有癌症患者的NRS评分高，升高了大多数细胞因子。患有主要抑郁症的癌症患者比没有重大抑郁症的NRS分数较高。 IL-1Rα与抑郁症状的网格评分正相关（回归系数，3.52？±1.18; p？= 004），但没有主要抑郁症。主要抑郁与抗炎细胞因子IL-4负相关（回归系数，α0.65？±0.26; P？= 013），但不是IL-1Rα。结论癌症患者的抑郁症状可能代表疾病行为，这可能具有来自主要抑郁症的不同细胞因子关联。疾病行为可能与炎性细胞因子的增加有关，而主要抑郁症可以通过未能充分解决炎症而诱导。我们的研究结果表明，细胞因子介导的干预措施可能具有价值，以治疗该类抑郁症。

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