Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study

Wu Shaowei; Gennings Chris; Wright Rosalind J.; Wilson Ander; Burris Heather H.; Just Allan C.; Braun Joseph M.; Svensson Katherine; Zhong Jia; Brennan Kasey J. M.; Dereix Alexandra; Cantoral Alejandra; Schnaas Lourdes; Tellez-Rojo Martha Maria; Wright Robert O.; Baccarelli Andrea A.

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Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study

机译：炎症相关基因的产前压力，甲基化，幼儿早期肥胖措施：肥胖，生长环境和社会压力队列研究中的编程研究

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Objective Maternal stress during pregnancy may influence childhood growth and adiposity, possibly through immune/inflammatory programming. We investigated whether exposure to prenatal stress and methylation in inflammation-related genes were associated with childhood adiposity in 424 mother-child pairs in Mexico City, Mexico.

机译：妊娠期间的客观母体压力可能会影响儿童生长和肥胖，可能通过免疫/炎症编程。我们调查了与炎症相关基因中的产前应激和甲基化是否与墨西哥城墨西哥城424母婴对的儿童肥胖有关。

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来源
《Psychosomatic Medicine: Journal of the American Psychosomatic Society》 |2018年第1期|共8页
作者
Wu Shaowei; Gennings Chris; Wright Rosalind J.; Wilson Ander; Burris Heather H.; Just Allan C.; Braun Joseph M.; Svensson Katherine; Zhong Jia; Brennan Kasey J. M.; Dereix Alexandra; Cantoral Alejandra; Schnaas Lourdes; Tellez-Rojo Martha Maria; Wright Robert O.; Baccarelli Andrea A.;
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作者单位

Peking Univ Sch Publ Hlth Dept Occupat &

Environm Hlth Sci 38 Xueyuan Rd Beijing 100191;

Mt Sinai Hosp Populat Hlth &

Sci Policy New York NY 10029 USA;

Kravis Childrens Hosp Dept Pediat New York NY USA;

Colorado State Univ Dept Stat Ft Collins CO 80523 USA;

Harvard Med Sch Beth Israel Deaconess Med Ctr Dept Neonatol &

Obstet Gynecol &

Reprod Biol;

Icahn Sch Med Mt Sinai Dept Prevent Med New York NY 10029 USA;

Brown Univ Sch Publ Hlth Dept Epidemiol Providence RI 02912 USA;

Icahn Sch Med Mt Sinai Dept Prevent Med New York NY 10029 USA;

Columbia Univ Mailman Sch Publ Hlth Dept Environm Hlth Sci New York NY 10027 USA;

Columbia Univ Mailman Sch Publ Hlth Dept Environm Hlth Sci New York NY 10027 USA;

Columbia Univ Mailman Sch Publ Hlth Dept Environm Hlth Sci New York NY 10027 USA;

Natl Inst Publ Hlth Ctr Res Nutr &

Hlth Cuernavaca Morelos Mexico;

Natl Inst Perinatol Div Res Community Intervent Mexico City DF Mexico;

Natl Inst Publ Hlth Ctr Res Nutr &

Hlth Cuernavaca Morelos Mexico;

Icahn Sch Med Mt Sinai Dept Prevent Med New York NY 10029 USA;

Columbia Univ Mailman Sch Publ Hlth Dept Environm Hlth Sci New York NY 10027 USA;

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原文格式 PDF
正文语种 eng
中图分类医学心理学、病理心理学;
关键词
adiposity; body mass index; inflammation; interleukin 6; methylation; prenatal stress;

机译：肥胖;体重指数;炎症;白细胞介素6;甲基化;产前压力;

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1. Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study [J] . Wu Shaowei, Gennings Chris, Wright Rosalind J., Psychosomatic Medicine: Journal of the American Psychosomatic Society . 2018,第1期

机译：炎症相关基因的产前压力，甲基化，幼儿早期肥胖措施：肥胖，生长环境和社会压力队列研究中的编程研究
2. 5.52 Toddler Cortisol Profiles Predicts Early Childhood Anxiety in a Prenatally Stressed Cohort: The QF2011 Queensland Flood Study [J] . Mia A. Mclean, Gabrielle Simcock, Guillaume Elgbeili, Journal of the American Academy of Child and Adolescent Psychiatry . 2018,第10期

机译：5.52幼儿皮质醇概况预测，在一个预压力的队列中的幼儿焦虑：QF2011昆士兰洪水研究
3. Depot- and obesity-related differences in adipogenesisAdipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting in adipose tissue hyperplasia. Although depot-specific differences and obesity-related modulation of adipocyte size are well documented, available data on adipogenesis and adipose tissue hyperplasia are less conclusive. Most studies support a reduction of adipogenesis in the obese state. Preadipocytes of the subcutaneous fat depot appear to be more responsive to adipogenic stimulation compared with those from visceral fat compartments in most studies. A number of studies support the notion that adipose tissue expansion through hyperplasia reduces ectopic lipid excess and obesity-related complications. Several genetic variants have been identified in the genes coding for adipogenesis-regulating proteins. While some of these variants have been clearly associated with the phenotypes of obesity and obesity-related alterations, available data highlight the importance of considering gene–gene and gene–diet interactions. [J] . Julie. Lessard, André. Tchernof Clinical lipidology. . 2012,第5期

机译：脂肪形成与肥胖相关的差异已知脂肪细胞肥大和增生分别通过增加脂肪细胞的大小和数量来促进脂质在脂肪组织中的存储。脂肪形成是导致脂肪组织增生的过程。尽管已经有很多文献记载了贮库特异性差异和肥胖相关的脂肪细胞大小调节，但有关脂肪形成和脂肪组织增生的可用数据尚无定论。大多数研究支持在肥胖状态下减少脂肪形成。在大多数研究中，与来自内脏脂肪区室的脂肪细胞相比，皮下脂肪库的前脂肪细胞似乎对脂肪刺激更为敏感。许多研究支持这样的观点，即通过增生的脂肪组织扩张可以减少异位脂质过多和肥胖相关的并发症。在编码脂肪形成调节蛋白的基因中已经鉴定出几种遗传变异。尽管其中一些变异与肥胖症的表型和与肥胖有关的改变明显相关，但现有数据突出了考虑基因-基因和基因-饮食相互作用的重要性。
4. Developmental Programming of Obesity and Metabolic Dysfunction: Role of Prenatal Stress and Stress Biology [C] . Sonja Entringer, PathikD. Wadhwa Nestle? Nutrition Workshop . 2013

机译：肥胖和代谢功能障碍的发育规划：产前压力和压力生物学的作用
5. Prenatal stress-mediated fetal programming of obesity in diet-induced obese and dietary resistant rats. [D] . Balasubramanian, Priya. 2012

机译：饮食诱发的肥胖和饮食抵抗大鼠的产前应激介导的胎儿肥胖编程。
6. Prenatal stress methylation in inflammation-related genes and adiposity measures in early childhood: the PROGRESS cohort study [O] . Shaowei Wu, Chris Gennings, Rosalind J. Wright, -1

机译：产前压力炎症相关基因中的甲基化和儿童早期的肥胖措施：PROGRESS队列研究
7. Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study [O] . Shaowei Wu, Chris Gennings, Rosalind J. Wright, 2018

机译：炎症相关基因的产前应激，甲基化，幼儿早期肥胖措施：肥胖，生长环境和社会压力队列研究中的编程研究

Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study

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