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首页> 外文期刊>Psychosomatics >Interventions to Improve Pharmacological Adherence Among Adults With Psychotic Spectrum Disorders and Bipolar Disorder: A Systematic Review
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Interventions to Improve Pharmacological Adherence Among Adults With Psychotic Spectrum Disorders and Bipolar Disorder: A Systematic Review

机译：改善有精神谱紊乱和双相障碍的成年人药理学依从性的干预措施：系统审查

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Background: It is unclear as to which interventions are effective at improving medication adherence in individuals with serious and persistent mental illness. The goal of this systematic review is to synthesize evidence examining the effectiveness, harms, and costs of interventions to improve medication adherence in patients with psychotic spectrum disorders and bipolar disorder. Methods: We conducted a systematic search of several electronic databases through January 2015 using a structured search strategy. Studies were included if they involved adult patients in general mental health settings, reported both measures of medication adherence and clinical outcomes, and were of sufficient methodological rigor. Studies were quality assessed and synthesized using established methods. Results: We idented 24 studies that met inclusion criteria. Overall, 20 studies addressed interventions in patients with psychotic spectrum disorders. These interventions varied widely, with generally mixed findings contributing to low or insufficient strength of evidence; studies involving family members and technology interventions were the most consistently associated with a positive effect; however, the strength of the evidence was low because of intervention heterogeneity. The evidence was insufficient to determine the effectiveness of interventions in patients with bipolar disorder. Conclusions: In individuals with psychotic spectrum disorders, interventions with family members or technology had the most consistent positive effect on adherence, although replication with objective adherence measures along with evaluation of harms and costs is needed. There was insufficient evidence to draw conclusions about interventions in individuals with bipolar disorder.
机译：背景：目前尚不清楚哪些干预措施是有效改善具有严重和持续精神疾病的个体药物依从性。该系统审查的目标是综合综合干预措施效果，危害和成本的证据，以改善精神谱系疾病和双相情感障碍患者的药物依从性。方法：通过结构化搜索策略，我们在2015年1月进行了系统搜索了几个电子数据库。如果他们涉及一般心理健康环境中的成年患者，则包括研究，报道了两种药物依从性和临床结果的措施，具有足够的方法论严谨性。使用建立方法评估和合成的质量研究。结果：我们确定了24项研究，符合纳入标准。总体而言，20项研究涉及精神病患者的干预措施。这些干预措施广泛变化，通常混合调查结果有助于低或不足的证据强度;涉及家庭成员和技术干预的研究是与积极效应有关的最始终如一的研究;然而，由于干预异质性，证据的强度低。证据不足以确定双相障碍患者的干预措施的有效性。结论：在有精神谱系障碍的个人中，与家庭成员或技术的干预措施对遵守具有最大的积极作用，尽管需要对客观依从性措施以及对危害和成本的评估进行复制。没有足够的证据来得出关于具有双相情感障碍的个体干预的结论。

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