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Treatment of Anxiety in Patients With Coronary Heart Disease: A Systematic Review

机译：冠心病患者焦虑的治疗：系统评价

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Background: Anxiety is common in patients with coronary heart disease (CHD) and is associated with an increased risk for adverse outcomes. There has been a relative paucity of studies concerning treatment of anxiety in patients with CHD. Objective: We conducted a systematic review to organize and assess research into the treatment of anxiety in patients with CHD. Methods: We searched CCTRICENTRAL, MEDLINE, EMBASE, PsycINFO, and CINAHL for randomized clinical trials conducted before October 2016 that measured anxiety before and after an intervention for patients with CHD. Results: A total of 475 articles were subjected to full text review, yielding 112 publications that met inclusion criteria plus an additional 7 studies from reference lists and published reviews, yielding 119 studies. Sample size, country of origin, study quality, and demographics varied widely among studies. Most studies were conducted with nonanxious patients. The Hospital Anxiety and Depression Scale and State -Trait Anxiety Inventory were the most frequently used instruments to assess anxiety. Interventions included pharmacological,counseling, relaxation-based, educational, or "alternative" therapies. Forty (33% of total) studies reported that the interventions reduced anxiety; treatment efficacy varied by study and type of intervention. Elevated anxiety was an inclusion criterion in only 4 studies, with inconsistent results. Conclusion: Although there have been a number of randomized clinical trials of patients with CHD that assessed anxiety, in most cases anxiety was a secondary outcome, and only one-third found that symptoms of anxiety were reduced with treatment. Future studies need to target anxious patients and evaluate the effects of treatment on anxiety and relevant clinical endpoints.
机译：背景：焦虑是冠心病（CHD）的患者常见，并且与不利结果的风险增加有关。有关于CHD患者治疗焦虑的研究有一种相对缺乏。目的：我们对组织和评估CHD患者焦虑的治疗进行组织和评估研究。方法：我们搜索了2016年10月前进行的随机临床试验的亚克里特朗伦，Medline，Embase，Psycinfo和Cinahl，以前和患有CHD患者的干预前后测量焦虑。结果：共有475篇文章进行全文审查，产生112个出版物，符合纳入标准加上参考清单和发表评论的额外7项研究，产生119项研究。样本大小，原产地，学习质量和人口统计学在研究中变得多样化。大多数研究是用饥饿患者进行的。医院焦虑和抑郁症和状态 - 焦虑库存是评估焦虑最常用的工具。干预包括药理学，咨询，放松，教育或“替代”疗法。四十（共33％）的研究报告说，干预措施降低了焦虑;治疗疗效通过研究和干预类型而变化。焦虑率为4项研究中是一种包含标准，结果不一致。结论：虽然有一些CHD患者的随机临床试验评估焦虑，但在大多数情况下，焦虑是次要结果，只有三分之一发现焦虑症状因治疗而减少。未来的研究需要针对焦虑的患者，并评估治疗对焦虑和相关临床终点的影响。

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