• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Quarterly Reviews of Biophysics >The evidence for open and closed exocytosis as the primary release mechanism
【24h】

The evidence for open and closed exocytosis as the primary release mechanism

机译：开放和闭合的卵尿精的证据作为主要释放机制

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Exocytosis is the fundamental process by which cells communicate with each other. The events that lead up to the fusion of a vesicle loaded with chemical messenger with the cell membrane were the subject of a Nobel Prize in 2013. However, the processes occurring after the initial formation of a fusion pore are very much still in debate. The release of chemical messenger has traditionally been thought to occur through full distention of the vesicle membrane, hence assuming exocytosis to be all or none. In contrast to the all or none hypothesis, here we discuss the evidence that during exocytosis the vesicle-membrane pore opens to release only a portion of the transmitter content during exocytosis and then close again. This open and closed exocytosis is distinct from kiss- and-run exocytosis, in that it appears to be the main content released during regular exocytosis. The evidence for this partial release via open and closed exocytosis is presented considering primarily the quantitative evidence obtained with amperometry.
机译：外尿量是细胞彼此沟通的基本过程。导致与细胞膜一起装入化学信使的囊泡融合的事件是2013年诺贝尔奖的主题。然而，在融合孔的初始形成后发生的过程仍然在辩论中。传统上，通过全面偏离囊泡膜来思考化学信使的释放，因此假设外尿量是全部的。与全部或无假设相比，这里我们讨论了卵尿量期间的证据，囊泡膜孔打开以在胞尿病期间仅释放一部分发射器含量，然后再次接近。这种开放和闭合的卵尿量不同于吻和运行的卵尿量，因为它似乎是常规卵尿量期间释放的主要内容。通过开放和闭合的卵尿作用的据考虑主要是使用安培测量获得的定量证据来呈现这种部分释放的证据。

著录项

  • 来源
    《Quarterly Reviews of Biophysics》 |2016年第2016期|共27页
  • 作者

    Ren Lin; Mellander Lisa J.; Keighron Jacqueline; Cans Ann-Sofie; Kurczy Michael E.; Svir Irina; Oleinick Alexander; Amatore Christian; Ewing Andrew G.;

  • 作者单位

    Chalmers Univ Technol Dept Chem &

    Chem Engn S-41296 Gothenburg Sweden;

    Univ Gothenburg Dept Chem &

    Chem Biol S-41296 Gothenburg Sweden;

    Chalmers Univ Technol Dept Chem &

    Chem Engn S-41296 Gothenburg Sweden;

    Chalmers Univ Technol Dept Chem &

    Chem Engn S-41296 Gothenburg Sweden;

    Chalmers Univ Technol Dept Chem &

    Chem Engn S-41296 Gothenburg Sweden;

    Univ Paris 06 Univ Paris 04 PSL Res Univ CNRS UMR PASTEUR 8640 Dept Chim Ecole Normale Sup 24 Rue Lhomond F-75005 Paris France;

    Univ Paris 06 Univ Paris 04 PSL Res Univ CNRS UMR PASTEUR 8640 Dept Chim Ecole Normale Sup 24 Rue Lhomond F-75005 Paris France;

    Univ Paris 06 Univ Paris 04 PSL Res Univ CNRS UMR PASTEUR 8640 Dept Chim Ecole Normale Sup 24 Rue Lhomond F-75005 Paris France;

    Chalmers Univ Technol Dept Chem &

    Chem Engn S-41296 Gothenburg Sweden;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号