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首页> 外文期刊>Ultrasound in Medicine and Biology >IMAGE MONITORING OF THE IMPAIRED PHAGOCYTIC ACTIVITY OF KUPFFER CELLS AND LIVER OXYGEN SATURATION IN A MOUSE CHOLANGITIS MODEL USING CONTRAST-ENHANCED ULTRASOUND IMAGING AND PHOTOACOUSTIC IMAGING
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IMAGE MONITORING OF THE IMPAIRED PHAGOCYTIC ACTIVITY OF KUPFFER CELLS AND LIVER OXYGEN SATURATION IN A MOUSE CHOLANGITIS MODEL USING CONTRAST-ENHANCED ULTRASOUND IMAGING AND PHOTOACOUSTIC IMAGING

机译：用对比增强超声成像和光声成像对小鼠胆管炎模型中kupffer细胞的吞噬活性受损的吞噬活性受损的图像监测

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Bile duct ligation (BDL) can cause cholangitis, which is known to induce impairedKupffer cell (KC) function and increased oxygen consumption in a mouse model. It is important to monitor changes in KC function and tissue oxygen saturation, both of which are critical factors in the progression of cholangitis. The purpose of this study is to investigate the impaired phagocytic activity of KC and liver oxygen saturation (sO(2)) in a mouse cholangitis model using contrast-enhanced ultrasound imaging (CEUS) and photoacoustic imaging (PAI). A mouse cholangitis model was created by ligation of the common bile duct (CBDL, n = 20), and the left intrahepatic bile duct (BDL-L, n = 19), both of which were compared with the non-ligation groups-right lobe measurement group after left intrahepatic bile duct ligation (BDL- R, n = 19) and the control group (n = 14). The echogenicity and sO(2) were measured by CEUS and PAI and the KC fraction was assessed at 1, 2 and 4 wk after ligation. We found a significantly lower echogenicity of the Kupffer phase in the CBDL and BDL-L groups compared with that in the control and BDL- R groups at 2 wk (p < .01). The CBDL and BDL-L groups showed a lower echogenicity than that of the BDL- R group at 4 wk (p,.01). We found a significantly lower sO(2) of the CBDL and BDL-L groups compared with that of the control and BDL- R groups at 4 wk (p < .01). The CBDL and BDL-L groups showed a higher KC fraction than that of the BDL- R and control groups at each time point (p < .01). In conclusion, our study suggests that the Sonazoid CEUS and PAI could be a useful tool for monitoring impaired KC phagocytic activity and the liver hypoxic state. (C) 2017 World Federation for Ultrasound in Medicine & Biology.
机译：胆管结扎（BDL）可引起胆管炎，已知诱导损伤的呕吐物细胞（KC）功能并增加小鼠模型中的氧气消耗。重要的是要监测KC功能和组织氧饱和度的变化，这两者都是胆管炎进展中的关键因素。本研究的目的是研究使用对比度增强的超声成像（CEUS）和光声成像（PAI）在小鼠胆管炎模型中KC和肝氧饱和度（SO（2））受损的吞噬活性（SO（2））。通过连接普通胆管（CBDL，N = 20）和左侧肝内胆管（BDL-L，N = 19），与非连接基团的右侧相比，产生小鼠胆管炎模型左肝内胆管连接后的叶测量组（BDL-R，N = 19）和对照组（N = 14）。通过CEUS和PAI测量回声和所以（2），并且在连接后在1,2和4周下评估KC级分。我们发现在CBD1和BDL-L中的Kupffer相的显着降低了Kupffer相的回声，而在2WK（P <0.01）中的对照和BDL-R基团中相比。 CBD1和BDL-L基团显示出低于4WK（P，0.01）的BDL-R组的升高性。与4WK（P <0.01）的对照和BDL-R基团相比，我们发现CBD1和BDL-L组的显着降低了（2）。 CBD1和BDL-L基团显示比每次点（P <0.01）的BDL-R和对照组的较高KC级分。总之，我们的研究表明，Sonaxoid Ceus和Pai可能是监测KC吞噬活性和肝缺氧状态受损的有用工具。 （c）2017年中国医学与生物学中超声波的世界联合会。

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