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首页> 外文期刊>Ultrasound in Medicine and Biology >MECHANICAL WEAKNESS OF THORACIC AORTA RELATED TO AGING OR DISSECTION PREDICTED BY SPEED OF SOUND WITH COLLAGENASE
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MECHANICAL WEAKNESS OF THORACIC AORTA RELATED TO AGING OR DISSECTION PREDICTED BY SPEED OF SOUND WITH COLLAGENASE

机译：与胶原酶的声速预测老化或解剖有关的胸主动脉的机械弱点

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摘要

Scanning acoustic microscopy reveals information on histology and speed of sound (SOS) through tissues. Slower SOS corresponds to lower stiffness. The aim of the present study was to investigate whether SOS values reflect the degree of degeneration with aging or dissection and whether enzymatic digestion susceptibility is distinct. The SOSs of media other than the atheromatous areas of normal and surgical dissections were measured and compared using medial degeneration grade (MDG) scores. To evaluate the damage rate, SOS was assessed after collagenase digestion. SOS scores negatively correlated with aging and MDG scores. Dissected aortas had higher SOS and MDG scores without age correlation. Collagenase digestion was present in all aortas, but older aortas were more injured than younger aortas. Dissected aortas were more vulnerable to collagenase. Older and dissected aortas expressed specific extracellular matrix components to compensate for mechanical weakness. The present method can evaluate mechanical weakness corresponding to histology to investigate the cause of rupture. (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
机译：扫描声学显微镜显示有关通过组织的组织学和声音速度（SOS）的信息。较慢的SOS对应于较低的刚度。本研究的目的是研究SOS值是否反映了衰老或解剖的退化程度，并酶消化易感性是否明显。测量和外科疏散性的晶体区域以外的介质的毛片，并使用内侧变性等级（MDG）分数进行比较。为了评估损伤率，在胶原酶消化后评估SOS。 SOS分数与老化和MDG分数负相关。解剖主动脉差异具有较高的SOS和MDG评分，无需年龄相关性。胶原酶消化存在于所有主动脉中，但较旧的主动脉比较年轻的主动脉更伤。解剖主体更容易受胶原酶。较旧的和解剖的主动脉表示特异的细胞外基质组分以补偿机械弱点。本方法可以评估对应于组织学的机械弱点，以研究破裂原因。 （c）2019年中国医学与生物学超声联联合会。版权所有。

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