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首页> 外文期刊>Urological Science >The Impact of the Fine Ambient Particle on Infertile Male’s Sperm Quality
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The Impact of the Fine Ambient Particle on Infertile Male’s Sperm Quality

机译：细环境粒子对不孕男性精子质量的影响

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Introduction: Infertility has been a major problem for several years. Previously, infertility was often attributed to female factors. Recently, however, male factors have been found to contribute to 50% of the infertility cases overall. Male infertility is a multifactorial issue. A genetic disorder, abnormal endocrine system, structural anomaly, and environmental causes could lead to male infertility. Studies have revealed a link between fine aft particles and decreased fertility. The aim of this study was to discover the effect of particulate matter 2.5 (PM2.5), representing environmental fine particles, on male infertility. Materials and Methods: We retrospectively collected data from patients diagnosed as having infertility and visited National Taiwan University Hospital from January 2015 to October 2017. We recorded each patient’s body weight, height, basic blood test, sperm analysis, and sex hormone profile. Aft quality data, especially PM2.5 concentration, were acquired from the Environmental Protection Administration of Taiwan. A total of 78 monitoring stations throughout Taiwan record PM2.5 concentrations (μg/m3) each hour automatically. Multivariate linear regression was used to detect independent factors affecting sperm count, concentration, motility, and morphology and sex hormone profile. Results: We observed regional and seasonal differences in the distributions of PM2.5 concentrations. In nearly all cities in Taiwan, the PM2.5 concentrations increased during early winter and continued to increase until next spring, with a peak around January and February. .In particular, regional differences were observed in winter. The peak PM2.5 concentrations in southern and northern cities in Taiwan ranged between 35 and 40 μg/m3 and between 18 and 23 μg/m3, respectively. PM2.5 in central Taiwan reached as high as 30 pL/m3. By contrast, the eastern part of Taiwan had the lowest peak PM2.5, which was mostly <15 μg/m3. The average 24-month PM2.5 concentration had a negative effect on sperm count, but the result was nonsignificant. Additionally, the effect of PM2.5 on sperm motility and morphology was minimal. Conclusion: In infertile Taiwanese men, there is a trend of a negative association between exposure to PM2.5 and sperm concentration and total sperm count. Exposure to ambient fine particles, especially PM2.5, might have a negative correlation with sperm quality, sex hormone balance, and the testicular microenvironment through different mechanisms.
机译：介绍：不孕症几年来一直是一个主要问题。以前，不孕症通常归因于女性因素。然而，最近，已经发现男性因素有助于整体不孕症的50％。男性不孕是一个多因素问题。遗传疾病，异常内分泌系统，结构异常和环境原因可能导致男性不孕症。研究揭示了细后颗粒之间的联系并降低了生育率。本研究的目的是发现颗粒物质2.5（PM2.5）的作用，代表雄性不孕症。材料和方法：我们回顾性地从2015年1月到2017年1月诊断为具有不孕症和访问国立台湾大学医院的患者的数据。我们记录了每位患者的体重，身高，基本血液测试，精子分析和性激素概况。从台湾的环保总局获得了AFT优质数据，特别是PM2.5集中。整个台湾总共78个监测站每小时一次记录PM2.5浓度（μg/ m3）。多变量线性回归用于检测影响精子计数，浓度，运动和形态和性激素型材的独立因素。结果：我们观察了PM2.5浓度分布的区域和季节性差异。在台湾几乎所有城市，PM2.5浓度在初冬冬季增加，直到明年春季持续增加，1月和2月左右。特别是，在冬季观察到区域差异。台湾南部和北部城市的峰值PM2.5浓度分别在35至40μg/ m 3之间，分别为18至23μg/ m3。台湾市中心PM2.5达到30张/ M3。相比之下，台湾的东部有最低的PM2.5，大部分是<15μg/ m3。平均24个月PM2.5浓度对精子计数产生负面影响，但结果是不显着的。另外，PM2.5对精子运动和形态的影响最小。结论：在不育的台湾男性中，暴露于PM2.5和精子浓度与精子数量之间存在负关联的趋势。暴露于环境细颗粒，特别是PM2.5，可以通过不同机制与精子质量，性激素平衡和睾丸微环境具有负相关性。

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