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首页> 外文期刊>Taiwan Veterinary Journal >PATHOGENICITY OF TAIWAN FERRET BADGER RABIES VIRUS IN RODENTS
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PATHOGENICITY OF TAIWAN FERRET BADGER RABIES VIRUS IN RODENTS

机译：台湾弗雷特獾狂犬病病毒的致病性

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摘要

The outbreaks of Taiwan ferret badger rabies reported in 2013 terminated the “rabies-free” status of Taiwan. Subsequent phylogenetic and divergence analyses have demonstrated that Taiwan ferret badger rabies virus (RABV-TWFB) might have emerged 100 years previously; however, most rabies cases were restricted to the Formosan ferret badger. In this study, pathogenic characteristics of mouse intracranial median lethal dose (MICLD50), median tissue culture infectious dose (TCID50), mortality development patterns, and peripheral infection of RABV-TWFB were evaluated in experimental rodents. The results revealed that RABV-TWFB had low MICLD50 titers, whereas TCID50 titers could not be determined. Compared with the typical street rabies virus, the overall mortality development patterns were later onset and slower progression. RABV-TWFB was unable to produce peripheral infection in the experimental rodents. Taken together, RABV-TWFB was less virulent to experimental rodents than other more typical RABV strains. To provide more appropriate strategies for epidemics management, the pathogenic properties of RABV-TWFB should be further investigated using ferret badgers and sympatric animals as models.
机译：2013年报告的台湾白貂獾狂犬病爆发终止了台湾的“无狂犬病”地位。随后的系统发育和分歧分析表明，台湾雪貂獾狂犬病病毒（Rabv-TwFB）可能先前已经出现了100年;然而，大多数狂犬病案件限于福克斯雪貂獾。在该研究中，在实验啮齿动物中评估了小鼠颅内中值致死剂量（MIDLD50），中值组织培养剂量（TCID50），死亡发育模式和外周感染的病原特征。结果表明，RABV-TWFB具有低MIDLD50滴度，而TCID50滴度无法确定。与典型的街头狂犬病病毒相比，整体死亡率发展模式后来发病，进展较慢。 Rabv-TWFB无法在实验啮齿动物中产生外周感染。一起服用，Rabv-TWFB比其他更典型的RABV菌株对实验啮齿动物的毒性较小。为提供更适合的流行病管理策略，应使用雪貂獾和Sympatric动物作为模型进一步调查Rabv-TWFB的致病性质。

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  • 来源
    《Taiwan Veterinary Journal》 |2018年第3期|共7页
  • 作者

    Ai-Ping Hsu; Chun-Hsien Tseng; Yu-Hua Shih; Kuo-Jung Tsai; Yi-Ta Lu; Chung-Hsi Chou; Wen-Jane Tu; Hsiang-Jung Tsai;

  • 作者单位

    *Animal Health Research Institute Council of Agriculture New Taipei City 25158 Taiwan;

    *Animal Health Research Institute Council of Agriculture New Taipei City 25158 Taiwan;

    *Animal Health Research Institute Council of Agriculture New Taipei City 25158 Taiwan;

    *Animal Health Research Institute Council of Agriculture New Taipei City 25158 Taiwan;

    *Animal Health Research Institute Council of Agriculture New Taipei City 25158 Taiwan;

    ?Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei 10615 Taiwan;

    *Animal Health Research Institute Council of Agriculture New Taipei City 25158 Taiwan;

    ?Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei 10615 Taiwan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 畜牧、动物医学、狩猎、蚕、蜂;
  • 关键词

    Pathogenicity; Rabies; Taiwan ferret badger rabies;

    机译：致病性;狂犬病;台湾雪貂獾狂犬病;

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