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首页> 外文期刊>Taiwan Veterinary Journal >USING SILDENAFIL TO TREAT A DOG WITH IDIOPATHIC MEGAESOPHAGUS
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USING SILDENAFIL TO TREAT A DOG WITH IDIOPATHIC MEGAESOPHAGUS

机译：使用Sildenafil治疗患有特发性巨型的狗

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摘要

A 4-month old, male intact, mixed-breed dog was referred for sudden onset of regurgitation for two weeks. Thoracic radiographs revealed severe dilatation of esophagus with barium aspiration pneumonia. Idiopathic megaesophagus (IME) was diagnosed after serial laboratory, endoscopic and computed tomographic examinations. Symptomatic treatment including medication for pneumonia, feeding through percutaneous endoscopic gastrostomy (PEG) tube with upright feeding position was performed at first, but regurgitation persisted. Sildenafil (1mg/kg, PO, BID) was then administrated for two weeks and regurgitation remitted one day after. Sildenafil was then tapered to half dose (0.5mg/kg, PO, BID) for another two weeks. During following-up thoracic radiography on 10 days after sildenafil administration, the degree of esophagus dilation significantly reduced. The clinical sign was completely resolved without relapse for more than 300 days. Sildenafil was reported having inhibitory effect of canine gastric contraction without affecting gastric emptying time. This effect could ameliorate persisting regurgitation after using PEG feeding directly into the stomach while bypassing the esophagus.
机译：一个4个月大的男性完整，混合品种狗被突然发作了两周的反流。胸部射线照片显示出与钡吸入肺炎的食管严重扩张。在串行实验室，内窥镜和计算的断层检查后诊断发作性兆噬藻（IME）。症状治疗包括肺炎的药物，通过经皮内窥镜胃术（PEG）管饲喂具有直立馈电位置的患者，但是持续的反流。然后，Sildenafil（1mg / kg，po，bid）在一天后递交两周并重新改造。然后将西地那非逐渐变成半剂量（0.5mg / kg，po，bid）两周。在西地那非给药后10天后在后续胸部射线照相中，食道扩张程度明显减少。临床标志完全解决了超过300天的复发。据报道，Sildenafil的抑制作用胃肠胃收缩而不影响胃排空时间。在绕过食道的同时使用PEG喂养后，这种效果可以在使用PEG进入胃后改善持续反流。

著录项

  • 来源
    《Taiwan Veterinary Journal》 |2020年第1期|共6页
  • 作者

    Yi-Ju Tu; Cheng-Shu Chung; Lee-Shuan Lin;

  • 作者单位

    *Laboratory of Veterinary Diagnostic Imaging Department of Veterinary Medicine College of Veterinary Medicine National Pingtung University of Science and Technology Pingtung Taiwan;

    ?Laboratory of Veterinary Surgery Department of Veterinary Medicine College of Veterinary Medicine National Pingtung University of Science and Technology Pingtung Taiwan;

    *Laboratory of Veterinary Diagnostic Imaging Department of Veterinary Medicine College of Veterinary Medicine National Pingtung University of Science and Technology Pingtung Taiwan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 畜牧、动物医学、狩猎、蚕、蜂;
  • 关键词

    Dog; Idiopathic megaesophagus; Sildenafil;

    机译：狗;特发性兆酚;西地那非;

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