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Assessment of conservative dietary management as a method for normalization of 24-h urine pH in stone formers

机译：评估保守膳食管理作为石材成型器中24-H尿液pH标准化的方法

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Low urine pH is a metabolic risk factor for stone formation. While medical therapy is typically prescribed (as urinary alkalinization), patients typically prefer dietary modifications. We aimed to assess capacity to alter urine pH with dietary management alone. We analyzed a retrospective cohort of stone formers seen between 2000 and 2015 with multiple 24-h urine collections (24hUC). Patients >= 18 years old with low urine pH ( = 6.0 on second 24hUC. Predictors were selected utilizing multivariable logistic regression. The database consisted of 2197 stone formers; 224 of these met inclusion criteria. On second 24hUC, 124 (55.4%) achieved a favorable pH >= 6.0. On univariable analysis, a second pH >= 6.0 was associated with high initial pH, low initial sulfate, younger age, increase in citrate/GIAA/urine volume, and decrease in ammonium (P = 6.0. The analysis demonstrated a corrected AUC of 0.853. These data suggest that certain dietary recommendations (increases in urine volume, citrate, GIAA, and decreased acid load) may normalize urine pH in a select group of patients. This may allow urologists to counsel patients with low urine pH on possibility of success with dietary modification alone.
机译：低尿pH值是石材形成的代谢危险因素。虽然通常规定医疗疗法（作为尿碱化），但患者通常更喜欢膳食修饰。我们的目标是通过单独使用膳食管理来评估改变尿pH的能力。我们分析了2000年至2015年间的备注队列的石材成型器，其中多个24小时尿液收集（24HUC）。患者> = 18岁，低尿pH（= 6.0，第二次24HUC。使用多变量逻辑回归选择预测器。数据库由2197个石头成型器组成;这些符合符合标准中的224个。在第二张24Huc，124（55.4％）达到124（55.4％）有利的pH> = 6.0。在单一的分析中，第二pH> = 6.0与高初始pH，低初始硫酸盐，较小的年龄有关，柠檬酸盐/尿量增加，并降低铵（P = 6.0。分析表明了0.853的校正AUC。这些数据表明某些膳食建议（尿量增加，柠檬酸盐，胶氮和酸载荷增加）可以在选择患者组中将尿pH标准化。这可能允许泌尿科医生向患者提供低劣的患者单独饮食改性成功的尿液pH值。

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