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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Typhoid Fever: Way Forward
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Typhoid Fever: Way Forward

机译：伤寒：前进

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摘要

The Tackling Typhoid supplement shows that typhoid fever continues to be a problem globally despite socioeconomic gains in certain settings. Morbidity remains high in many endemic countries, notably in sub-Saharan Africa and South Asia. In addition, antimicrobial resistance is a growing issue that poses a challenge for clinical management. The findings from this supplement revealed that outside of high-income countries, there were few reliable population-based estimates of typhoid and paratyphoid fever derived from surveillance systems. This indicates the need for monitoring systems that can also characterize the effectiveness of interventions, particularly in low-and middle-income settings. The country case studies indicated that gains in economic conditions, education, and environmental health may be associated with reductions in typhoid fever burden. Over the study period, the effect is mainly notable in countries with higher baseline levels of economic development, female literacy, and investments in public sanitation. High burden countries must continue to invest in strategies at the local level to address environmental factors such as access to safe drinking water and improved public sanitation that are known to interrupt transmission or diminish the risk of acquiring typhoid. Developing more effective vaccines and incorporating appropriate immunization strategies that target populations with the greatest risk could potentially alleviate disease burden.
机译：尽管某些环境中的社会经济增益，但伤害的牙膏补充表明，伤寒率仍然是全球的问题。许多地方国家的发病率仍然很高，特别是在撒哈拉以南非洲和南亚。此外，抗微生物抗性是一种日益增长的问题，对临床管理构成挑战。该补充的调查结果显示，在高收入国家之外，少量可靠的人口估计来自监测系统的伤寒和副伤寒。这表示需要监控系统，这些系统也可以表征干预措施的有效性，特别是在低收入和中等收入设置中。该国家案例研究表明，经济状况，教育和环境健康方面的收益可能与伤寒热负担的减少有关。在研究期间，效果主要是在经济发展的基线水平，女性识字和公共卫生范围内的国家。高负荷国家必须继续投资当地一级的战略，以解决进入安全饮用水和改善中断传输或减少收购伤寒风险的公共卫生等待的环境因素。培养更有效的疫苗并纳入适当的免疫策略，旨在具有最大风险的群体可能会缓解疾病负担。

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