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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Congenital Chagas Disease in the Ecuadorian Amazon: Maternal Screening at Delivery and Evaluation of Risk Factors Associated with Vector Exposure
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Congenital Chagas Disease in the Ecuadorian Amazon: Maternal Screening at Delivery and Evaluation of Risk Factors Associated with Vector Exposure

机译：先天性芝麻疾病在厄瓜多尔亚马逊：母体筛选在交付和评估与传染媒介曝光相关的风险因素

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摘要

Congenital infection with Trypanosoma cruzi remains a major route for Chagas disease transmission in endemic and non-endemic regions. We evaluated an intervention strategy aimed to detect congenital Chagas disease cases at a major hospital in the Ecuadorian Amazon via cord blood analysis at the time of delivery. All women giving birth at the hospital during the study period (191) were invited to participate. Among them, two (1.0%) did not adjust to the inclusion criteria and four (2.1%) declined to participate in the study, showing the intervention had good acceptability among the mothers. It was possible to obtain cord blood samples during 146 of the deliveries, and only one woman was found to be seropositive, without evidence of transmission to the newborn at delivery or 8 months later. In addition, sociodemographic and economic characterization of the study population revealed that few women had previous knowledge about Chagas disease (16.1%) whereas more than half (62.5%) recognized the vector. Recognizing the vector and having seen it indoors were associated with women from rural families, involved in agriculture, and hunting in the forest. Interestingly, most women (87.3%) reported having easy access to Ecuador's national health system, suggesting serological screening during prenatal visits would be of value in this province. With a proper prenatal screening system in place, cord blood screening would allow for timely detection of T. cruzi infection in newborns from both seropositive women and the minority (2.1%) of women who do not comply with prenatal care visits.
机译：先天性感染睾丸瘤Cruzi仍然是流行和非地方性区域中的Chagas疾病传播的主要途径。我们评估了一种干预策略，旨在通过在交付时通过脐带血分析来检测厄瓜多尔亚马逊的主要医院的先天性噬菌体病例。邀请所有妇女在学习期间在医院出生（191年）参加。其中，两（1.0％）没有适应纳入标准，四（2.1％）拒绝参加该研究，表明干预措施在母亲之间具有良好的可接受性。在交付的146期间，可以获得脐带血样品，只发现一个女人被发现是血清阳性，而没有证据表明在递送到新生儿或8个月后。此外，研究人群的社会造影和经济特征透露，少数女性以前有关钦萨病的了解（16.1％），而超过一半（62.5％）认识到载体。认识到载体并看到它在室内与来自农村家庭的女性有关，参与农业，森林狩猎。有趣的是，大多数女性（87.3％）报告旨在轻松获得厄瓜多尔国家卫生系统，暗示在产前访问期间的血清学筛查将是这个省的价值。通过适当的产前筛查系统，脐带血筛查将允许及时检测来自血清阳性女性的新生儿和少数群体（2.1％）的妇女不符合产前护理访问。

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