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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Taking a bite out of malaria: Controlled human malaria infection by needle and syringe
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Taking a bite out of malaria: Controlled human malaria infection by needle and syringe

机译:从疟疾中咬一口:针刺和注射器受控制的人类疟疾感染

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In this issue of AJTMH, Roestenberg and colleagues report that healthy adults can be infected by the intradermal injection of aseptic, purified, vialed, cryopreserved Plasmodium falciparum sporozoites (PfSPZ Challenge). Because of the potential of this "challenge in a bottle" to standardize and dramatically expand the use of controlled human malaria infections (CHMI) for assessment of malaria vaccines, drugs, and diagnostics, and naturally acquired immunity and innate resistance to malaria, this approach to CHMI may well turn out to be one of the major achievements in malaria vaccine research and development of the past half-century.
机译:在这个问题的AJTMH,Roestenberg及其同事报告称,健康的成年人可以感染皮内注射无菌,纯化的,瓶颈,冷冻保存的疟原虫(PFSPZ挑战)。 由于这种“瓶子中的挑战”的潜力来标准化和显着扩大使用受控人类疟疾感染(CHMI)进行评估疟疾疫苗,药物和诊断,并且自然获得的免疫和对疟疾的先天性抗性,这种方法 对于Chmi可能会成为过去半个世纪疟疾疫苗研究和发展的主要成就之一。

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