Refractory and/or Relapsing Cryptococcosis Associated with Acquired Immune Deficiency Syndrome: Clinical Features, Genotype, and Virulence Factors of Cryptococcus spp. Isolates

Nascimento Erika; Vitali Lucia H.; Tonani Ludmilla; Von Zeska Kress Marcia R.; Takayanagui Osvaldo M.; Martinez Roberto

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Refractory and/or Relapsing Cryptococcosis Associated with Acquired Immune Deficiency Syndrome: Clinical Features, Genotype, and Virulence Factors of Cryptococcus spp. Isolates

机译：与获得的免疫缺陷综合征相关的难治性和/或复发密码细胞：临床特征，基因型和隐睾SPP的毒力因子。孤立

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Refractory and relapsing crytocococcosis in acquired immune deficiency syndrome (AIDS) patients have a poor prognosis. The risk factors for this complicated infection course were evaluated by comparing refractory and/or relapsing cryptococcosis in human immunodeficiency virus-coinfected patients (cohort 1) with another group of AIDS patients who adequately responded to antifungals (cohort 2). Except for one isolate of Cryptococcus gattii from a cohort 2 case, all other isolates were identified as Cryptococcus neoformans var. grubii, sex type a, genotype VNI, including Cryptococcus reisolated from the relapse or in the refractory state. No differences were observed with respect to Cryptococcus capsule size and in the melanin and phospholipase production. The cohort 1 patients presented higher prevalence of cryptococcemia, cerebral dissemination, chronic liver disease, and leucopenia, and have increased death rate. Apparently, the refractory and/or relapsing cryptococcosis in the AIDS patients were more related to the host and the extent of the infection than to the fungal characteristics.

机译：获得的免疫缺陷综合征（艾滋病）患者的难治性和复发性低温细胞病患者预后差。通过比较人免疫缺陷病毒 - 繁殖患者（COHORT 1）中的耐火性和/或复发密集细胞病毒，与另一组艾滋病患者进行了充分应对抗真菌（COHORT 2）来评估这种复杂的感染过程的危险因素。除了来自群组2例中的一个分离的水蛭球菌，所有其他分离物均被鉴定为Cryptococcus neoformans var。 Grubii，性型A，基因型VNI，包括从复发或耐火材料中重新坐出的碱基。在密集皮卡囊粒度和黑色素和磷脂酶生产中没有观察到差异。群组1名患者呈现出较高的隐性皮肤病，脑传播，慢性肝病和白细胞患病率，并增加了死亡率。显然，艾滋病患者的难治性和/或复发性密集细胞症与宿主更相关，感染程度比真菌特征更相关。

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来源
《The American Journal of Tropical Medicine and Hygiene》 |2016年第5期|共7页
作者
Nascimento Erika; Vitali Lucia H.; Tonani Ludmilla; Von Zeska Kress Marcia R.; Takayanagui Osvaldo M.; Martinez Roberto;
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作者单位

Univ Sao Paulo Ribeirao Preto Med Sch Dept Internal Med Ribeirao Preto SP Brazil;

Univ Sao Paulo Ribeirao Preto Med Sch Dept Internal Med Ribeirao Preto SP Brazil;

Univ Sao Paulo Sch Pharmaceut Sci Ribeirao Preto Ribeirao Preto SP Brazil;

Univ Sao Paulo Sch Pharmaceut Sci Ribeirao Preto Ribeirao Preto SP Brazil;

Univ Sao Paulo Ribeirao Preto Med Sch Dept Neurosci &

Behav Ribeirao Preto SP Brazil;

Univ Sao Paulo Ribeirao Preto Med Sch Dept Internal Med Ribeirao Preto SP Brazil;

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正文语种 eng
中图分类地方病学;
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1. Refractory and/or Relapsing Cryptococcosis Associated with Acquired Immune Deficiency Syndrome: Clinical Features, Genotype, and Virulence Factors of Cryptococcus spp. Isolates [J] . Nascimento Erika, Vitali Lucia H., Tonani Ludmilla, The American Journal of Tropical Medicine and Hygiene . 2016,第5期

机译：与获得的免疫缺陷综合征相关的难治性和/或复发密码细胞：临床特征，基因型和隐睾SPP的毒力因子。孤立
2. Cryptococcus neoformans clinical isolates from Serbia - genotypes, antifungal susceptibility and virulence [J] . Pekmezovic M. G., Barac A., Arsenijevic V. S. Arsic, Mycoses: Diagnosis, therapy and prophylaxis of fungal diseases . 2014,第Suppla1期

机译：来自塞尔维亚的新型隐球菌临床分离株-基因型，抗真菌药性和毒力
3. Assessing factors influencing university students to uptake voluntary counselling and testing (VCT) of human immune deficiency virus/acquired immune deficiency syndrome (HIV/AIDS) [J] . Lawrence Meda Journal of AIDS and HIV Research . 2013,第6期

机译：影响大学生对人类免疫缺陷病毒/获得性免疫缺陷综合征（艾滋病毒/艾滋病）的吸收自愿咨询和测试（VCT）的评估因素
4. Prevalence and related factors of anemia among human immunodeficiency virus(HIV)/acquired immune deficiency syndrome (AIDS) outpatients in resources limited region of China [C] . Zhibin Liu, Yantao Jin, Jiping Yang, IEEE International Conference on Bioinformatics and Biomedicine . 2013

机译：资源有限地区人类免疫缺陷病毒（HIV）/后天免疫缺陷综合症（AIDS）门诊患者贫血患病率及相关因素
5. Risk of retinal detachment and vision loss in patients with cytomegalovirus retinitis and the acquired immune deficiency syndrome (Immune deficiency). [D] . Kempen, John Harold. 2001

机译：巨细胞病毒性视网膜炎和获得性免疫缺陷综合征（免疫缺陷）患者视网膜脱离和视力丧失的风险。
6. Refractory and/or Relapsing Cryptococcosis Associated with Acquired Immune Deficiency Syndrome: Clinical Features Genotype and Virulence Factors of Cryptococcus spp. Isolates [O] . Erika Nascimento, Lucia H. Vitali, Ludmilla Tonani, 2016

机译：与获得性免疫缺陷综合征相关的难治性和/或复发性隐球菌病：隐球菌属的临床特征基因型和毒力因子。隔离物
7. Outcome of patients with relapsed/refractory acquired immune deficiency syndrome-related lymphoma diagnosed 1999–2008 and treated with curative intent in the AIDS Malignancy Consortium [O] . Ulas D. Bayraktar, Juan Carlos Ramos, Adam Petrich, 2012

机译：复发/难治性获得的免疫缺陷综合征相关淋巴瘤患者的结果诊断为1999 - 2008，并在艾滋病恶性联盟中治疗治疗意图

Refractory and/or Relapsing Cryptococcosis Associated with Acquired Immune Deficiency Syndrome: Clinical Features, Genotype, and Virulence Factors of Cryptococcus spp. Isolates

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