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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes
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Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes

机译：锥虫瘤Cruzi感染诱导心肌细胞中的Pannexin-1通道开口

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摘要

Trypanosoma cruzi, the etiological agent of Chagas diseases, invades the cardiac tissue causing acute myocarditis and heart electrical disturbances. In T. cruzi invasion, the parasite induces [Ca2+](i) transients in the host cells, an essential phenomenon for invasion. To date, knowledge on the mechanism that elicits transients of [Ca2+](i) during the infection of cardiac myocytes has not been fully characterized. Pannexin1 (Panx1) channel are poorly selective channels found in all vertebrates that serve as a pathway for ATP release. In this article, we demonstrate that T. cruzi infection results in the opening of Panx1 channels in cardiac myocytes. We show that pharmacological blockade of Panx1 channels inhibits T. cruzi-induced [Ca2+](i) transients and invasion in cardiac myocytes. Our results indicate that opening of Panx1 channels are required for T. cruzi invasion in cardiac myocytes, and we propose that targeting Panx1 channel could provide new potential therapeutic approaches to treat Chagas disease.
机译：赤盼瘤Cruzi，粘胶疾病的病因症，侵入了急性心肌炎和心脏电气干扰的心脏组织。在T.Cruzi侵袭中，寄生虫诱导宿主细胞中的[Ca2 +]（I）瞬变，是侵袭的重要现象。迄今为止，关于在心肌细胞感染期间引发[CA2 +]（I）瞬变的机制的知识尚未完全表征。 Pannexin1（Panx1）通道是在所有脊椎动物中发现的选择性通道不良，用作ATP释放的途径。在本文中，我们证明T.Cruzi感染导致心脏肌细胞的Panx1通道的开度。我们表明Panx1通道的药理学阻滞抑制了Cruzi诱导的[Ca2 +]（i）瞬变和心脏肌细胞的侵袭。我们的结果表明，心肌细胞中的T.Cruzi侵袭需要PanX1通道的开放，我们提出靶向Panx1通道可以提供新的潜在治疗钩蛇疾病的治疗方法。

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    Barria Ivan; Guiza Juan; Cifuentes Fredi; Zamorano Pedro; Saez Juan C.; Gonzalez Jorge; Vega Jose L.;

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    Univ Antofagasta Antofagasta Inst Expt Physiol Lab EPhyL Angamos 601 Antofagasta Chile;

    Univ Antofagasta Antofagasta Inst Expt Physiol Lab EPhyL Angamos 601 Antofagasta Chile;

    Univ Antofagasta Antofagasta Inst Expt Physiol Lab EPhyL Angamos 601 Antofagasta Chile;

    Univ Antofagasta Dept Biomed Neurobiol Lab Antofagasta Chile;

    Pontificia Univ Catolica Chile Fac Ciencias Biol Dept Fisiol Santiago Chile;

    Univ Antofagasta Mol Parasitol Unit Fac Hlth Sci Antofagasta Chile;

    Univ Antofagasta Antofagasta Inst Expt Physiol Lab EPhyL Angamos 601 Antofagasta Chile;

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  • 正文语种 eng
  • 中图分类 地方病学;
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