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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Use of Antibody Tools to Provide Serologic Evidence of Elimination of Lymphatic Filariasis in The Gambia
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Use of Antibody Tools to Provide Serologic Evidence of Elimination of Lymphatic Filariasis in The Gambia

机译：使用抗体工具提供消除冈比亚淋巴丝虫病的血清学证据

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A current need in the global effort to eliminate lymphatic filariasis (LF) is the availability of reliable diagnostic tools that can be used to guide programmatic decisions, especially decisions made in the final stages of the program. This study conducted in The Gambia aimed to assess antifilarial antibody levels among populations living in historically highly LF-endemic areas and to evaluate the use of serologic tools to confirm the interruption of LF transmission. A total of 2,612 dried blood spots (DBSs) collected from individuals aged 1 year and above from 15 villages were tested for antibodies to Wb123 by enzyme-linked immunosorbent assay (ELISA). A subset of DBS (N = 599) was also tested for antibodies to Bm14 by ELISA. Overall, the prevalence of Wb123 was low (1.5%, 95% confidence interval [CI] 1.1-2.1%). In 7 of 15 villages (46.7%), there were no Wb123-positive individuals identified. Individuals with positive responses to Wb123 ranged in age from 3 to 100 years. Overall, Bm14 prevalence was also low (1.5%, 95% CI 0.7-2.8%). Bm14 positivity was significantly associated with older age (P 0.001). The low levels of antibody responses to Wb123 observed in our study strongly suggest that sustainable LF transmission has likely ceased in The Gambia. In addition, our results support the conclusion that serologic tools can have a role in guiding programmatic decision making and supporting surveillance.
机译：目前在全球努力消除淋巴丝虫病（LF）的需求是可用于指导方案决策的可靠诊断工具，特别是在计划的最终阶段作出的决定。该研究在冈比亚进行了旨在评估生活在历史上高度LF流行区域的种群的防污性抗体水平，并评估使用血清型工具来确认LF传输的中断。通过酶联免疫吸附试验（ELISA）对从1年和15岁的胞质中收集的2,612次及以上的血液斑（DBS）从15岁以上的群中收集的血斑（ELISA）进行抗体。还通过ELISA测试DBS（n = 599）的抗体对BM14的抗体。总体而言，WB123的患病率低（1.5％，95％置信区间[CI] 1.1-2.1％）。在15个村庄的7个（46.7％）中，没有发现WB123阳性的个体。对WB123的积极反应的个人从3到100年的年龄范围。总体而言，BM14患病率也低（1.5％，95％CI 0.7-2.8％）。 BM14阳性与年龄较大的阳性显着相关（P <0.001）。我们研究中观察到的WB123的低水平抗体反应强烈表明，可持续的LF传播可能在冈比亚停止。此外，我们的结果支持结论，血清系统工具可以在指导方案决策和支持监测方面具有作用。

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