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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >The Burden of Dengue Fever and Chikungunya in Southern Coastal Ecuador: Epidemiology, Clinical Presentation, and Phylogenetics from the First Two Years of a Prospective Study
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The Burden of Dengue Fever and Chikungunya in Southern Coastal Ecuador: Epidemiology, Clinical Presentation, and Phylogenetics from the First Two Years of a Prospective Study

机译：南沿海厄瓜多尔登革热和千井村的负担：流行病学，临床介绍和前两年的前瞻性研究的临床介绍

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摘要

Here, we report the findings from the first 2 years (2014-2015) of an arbovirus surveillance study conducted in Machala, Ecuador, a dengue-endemic region. Patients with suspected dengue virus (DENV) infections (index cases, N= 324) were referred from five Ministry of Health clinical sites. A subset of DENV-positive index cases (N= 44) were selected, and individuals from the index household and four neighboring homes within 200 m were recruited (N = 400). Individuals who entered the study, other than the index cases, are referred to as associates. In 2014, 70.9% of index cases and 35.6% of associates had acute or recent DENV infections. In 2015, 28.3% of index cases and 12.8% of associates had acute or recentDENV infections. For every DENV infection captured by passive surveillance, we detected an additional three acute or recent DENV infections in associates. Of associates with acuteDENV infections, 68% reported dengue-like symptoms, with the highest prevalence of symptomatic acute infections in children aged less than 10 years. The first chikungunya virus (CHIKV) infections were detected on epidemiological week 12 in 2015; 43.1% of index cases and 3.5% of associates had acute CHIKV infections. No Zika virus infections were detected. Phylogenetic analyses of isolates of DENV from 2014 revealed genetic relatedness and shared ancestry of DENV1, DENV2, and DENV4 genomes from Ecuador with those from Venezuela and Colombia, indicating the presence of viral flow between Ecuador and surrounding countries. Enhanced surveillance studies, such as this, provide high-resolution data on symptomatic and inapparent infections across the population.
机译：在这里，我们从马拉马拉，厄瓜多尔，登革热地区举行的Arbovirus监测研究中向厄瓜多勒监督研究的前2岁（2014-2015）报告了调查结果。涉嫌登革热病毒（DENV）感染（指数案件，N = 324）的患者被提及五个卫生部临床部位。选择了丹麦阳性指数案例（n = 44）的子集，招募来自指数家庭和200米内的四个相邻家庭的个体（n = 400）。除了索引案例之外，进入该研究的个人被称为员工。 2014年，70.9％的指数案件和35.6％的员工患有急性或最近的丹佛感染。 2015年，28.3％的指数案例和12.8％的员工具有急性或最新的感染。对于被动监测捕获的每个DenV感染，我们在员工中检测到额外的三种急性或最近的Denv感染。伴随着缩进的症状，68％的症状，令人遗憾的症状，症状的症状最高，儿童症状急性感染率不到10年。第一个Chikungunya病毒（Chikv）感染于2015年的流行病学周内检测到; 43.1％的指数案例和3.5％的员工患有急性Chikv感染。没有检测到Zika病毒感染。 2014年丹佛塞维分离株的系统发育分析揭示了厄瓜多尔和哥伦比亚的厄瓜多尔的遗传相关性和共享祖先，表明厄瓜多尔和周边国家之间存在病毒流动。增强的监测研究，如此，为整个人口的症状和不吸引感染提供高分辨率数据。

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