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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Vector-Borne Disease is a Common Cause of Hospitalized Febrile Illness in India
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Vector-Borne Disease is a Common Cause of Hospitalized Febrile Illness in India

机译：载体传导疾病是印度住院的常见原因

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摘要

Acute febrile illness (AFI) is a major cause of morbidity and mortality in India and other resource-limited settings, yet systematic etiologic characterization of AFI has been limited. We prospectively enrolled adults (N = 970) and children (age 6 months to 12 years, N= 755) admitted with fever from the community to Sassoon General Hospital in Pune, India, from July 2013 to December 2015. We systematically obtained a standardized clinical history, basic laboratory testing, and microbiologic diagnostics on enrolled participants. Results from additional testing ordered by treating clinicians were also recorded. A microbiological diagnosis was found in 549 (32%) participants; 211 (12%) met standardized case definitions for pneumonia and meningitis without an identified organism; 559 (32%) were assigned a clinical diagnosis in the absence of a confirmed diagnosis; and 406 (24%) had no diagnosis. Vector-borne diseases were the most common cause of AFI in adults including dengue (N = 188, 19%), malaria (N = 74, 8%), chikungunya (N = 15, 2%), and concurrent mosquito-borne infections (N = 23, 2%) occurring most frequently in the 3 months after the monsoon. In children, pneumonia was the most common cause of AFI (N = 214, 28%) and death. Bacteremia was found in 68 (4%) participants. Central nervous system infections occurred in 58 (6%) adults and 64 (8%) children. Etiology of AFI in India is diverse, highly seasonal, and difficult to differentiate on clinical grounds alone. Diagnostic strategies adapted for season and age may reduce diagnostic uncertainty and identify causative organisms in treatable, fatal causes of AFI.
机译：急性发热疾病（AFI）是印度发病率和死亡率的主要原因和其他资源有限的环境，但AFI的系统性病因表征受到限制。我们宣传的成年人（n = 970）和儿童（6个月至12岁，N = 755），从社区到2013年7月至2015年7月，从社区到SASSOON总医院的发烧。我们系统地获得了标准化注册参与者的临床历史，基础实验室检测和微生物诊断。还记录了通过治疗临床医生订购的额外测试的结果。在549（32％）参与者中发现了微生物诊断; 211（12％）在没有鉴定的生物体的情况下满足肺炎和脑膜炎的标准化案例定义;在没有确诊的诊断的情况下，将559（32％）分配了临床诊断; 406（24％）没有诊断。载体传播疾病是AFI中最常见的成年人原因，包括登革热（n = 188,19％），疟疾（n = 74,8％），chikungunya（n = 15,2％），并同时蚊子感染（n = 23,2％）在季风后3个月内最常发生。在儿童中，肺炎是AFI最常见的原因（n = 214,28％）和死亡。在68名（4％）参与者中发现了菌血症。中枢神经系统感染发生在58（6％）成人和64名（8％）儿童中发生。印度AFI的病因是多元化的，高度季节性的，并且难以单独地区分临床理由。适用于季节和年龄的诊断策略可能会降低诊断的不确定性，并识别治疗，致命原因的致病性生物。

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    Robinson Matthew L.; Kadam Dileep; Khadse Sandhya; Balasubramanian Usha; Raichur Priyanka; Valvi Chhaya; Marbaniang Ivan; Kanade Savita; Sachs Jonathan; Basavaraj Anita; Bharadwaj Renu; Kagal Anju; Kulkarni Vandana; Zenilman Jonathan; Nelson George; Manabe Yukari C.; Kinikar Aarti; Gupta Amita; Mave Vidya;

  • 作者单位

    Johns Hopkins Univ Sch Med 600 N Wolfe St Phipps 540 Baltimore MD 21287 USA;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Byramjee Jeejeebhoy Govt Med Coll Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Sch Med 600 N Wolfe St Phipps 540 Baltimore MD 21287 USA;

    Vanderbilt Univ Sch Med Nashville TN 37212 USA;

    Johns Hopkins Univ Sch Med 600 N Wolfe St Phipps 540 Baltimore MD 21287 USA;

    Johns Hopkins Univ Byramjee Jeejeebhoy Govt Med Coll Clin Res Site Pune Maharashtra India;

    Johns Hopkins Univ Sch Med 600 N Wolfe St Phipps 540 Baltimore MD 21287 USA;

    Johns Hopkins Univ Sch Med 600 N Wolfe St Phipps 540 Baltimore MD 21287 USA;

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  • 正文语种 eng
  • 中图分类 地方病学;
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