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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Evaluation of Immunoglobulin G Responses to Plasmodium falciparum and Plasmodium vivax in Malian School Children Using Multiplex Bead Assay
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Evaluation of Immunoglobulin G Responses to Plasmodium falciparum and Plasmodium vivax in Malian School Children Using Multiplex Bead Assay

机译：利用多重珠子测定评价玛丽安学童疟原虫和疟原虫疟原虫疟原虫疟原虫的评价

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摘要

Malaria serology through assaying for IgG against Plasmodium spp. antigens provides evidence into the infection history for an individual. The multiplex bead assay (MBA) allows for detection of IgG against multiple Plasmodium spp., and can be especially useful in many regions where Plasmodium falciparum is of primary clinical focus, but other species are co-endemic. Dried blood spots were collected from 805 Malian children attending 42 elementary schools in the regions of Mopti, Sikasso, Koulikoro, and Bamako capital district, and IgG assayed by MBA. As southern Mali is known to be holoendemic for P. falciparum, merozoite surface protein 1 19-kDa subunit (MSP-1_(42)) and apical membrane antigen 1 (AMA-1) antigens were included for serology against this parasite. Responses to these antigens both provided high estimates for lifetime exposure, with 730 (90%) children with IgG antibodies for MSP-142, 737 (91 %) for AMA-1, and 773 (96%) positive for either or both. Also included was the antigen Plasmodium vivax MSP-1_(19), against which 140 (17.4%) children were found to have antibodies. Increases in antibody titers with older age were clearly seen with the P. falciparum antigens, but not with the P. vivax antigen, likely indicating more of a sporadic, rather than sustained transmission for this species. The MBA provides effective opportunities to evaluate malaria transmission through serological analysis for multiple Plasmodium species.
机译：疟疾血清学通过针对疟原虫SPP的IgG进行测定。抗原为个人提供了证据。多重珠子测定（MBA）允许检测对多个疟原虫SPP的IgG，并且可以在许多地区尤其有用，其中疟原虫是初级临床焦点的，但其他物种是共同的。从Mopti，Sikasso，Koulikoro和Bamako首都区的地区出席42所小学的805名小学，以及MBA测定的IgG，从805名小学收集了干血斑。由于南部马里被众所周知，对于P. falciparum，Merozoite表面蛋白质1 19-KDA亚基（MSP-1_（42））和顶端膜抗原1（AMA-1）抗原被包括在血寄生中的血清学。对这些抗原的反应均提供高估计的寿命暴露，730（90％）儿童为AMA-1的MSP-142,737（91％）的IgG抗体和773（96％）阳性。还包括抗原疟原虫MSP-1_（19），发现140（17.4％）患儿有抗体。用P. falciparum抗原清楚地看到具有较大年龄的抗体滴度的抗体滴度，但不适用于P.Vivax抗原，可能表明更多散发性，而不是这种物种的持续传播。 MBA提供了通过对多种疟原虫种类进行血清学分析来评估疟疾传播的有效机会。

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