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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Elevated Levels of Urinary 8-oxodG Correlate with Persistent Periductal Fibrosis after Praziquantel Treatment in Chronic Opisthorchiasis
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Elevated Levels of Urinary 8-oxodG Correlate with Persistent Periductal Fibrosis after Praziquantel Treatment in Chronic Opisthorchiasis

机译：尿8-oxodg升高的尿8-氧代纤维化在慢性Opisthorchiasis中吡喹酮治疗后相关

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Previous studies demonstrated that urinary 8-oxodG is a predictive biomarker for Opisthorchis viverrini (OV)-associated hepatobiliary disease (HBD) and cholangiocarcinoma (CCA). This study examined the effects of praziquantel treatment on the profile of urinary 8-oxodG in relation to HBD status. Infection with OV, levels of urinary 8-oxodG, and HBD status in terms of periductal fibrosis (PDF) assessed by abdominal ultrasonography (US) were monitored and compared in cohorts of participants in Khon Kaen, Thailand, before and 1 year after praziquantel treatment. Urinary 8-oxodG levels significantly decreased after treatment compared with the baseline level in OV-infected participants who had no HBD (PDF negative; PDF-ve) (N = 14). Levels of 8-oxodG were unchanged after treatment in OV-infected subjects (OV+ve) who had positive PDF (N = 52). Within the positive PDF (PDF+ve) group who became PDF-ve after treatment, there was no significant change in 8-oxodG levels between pre- and posttreatment (reversible PDF = 65.3%). In those who had persistent PDF+ve at both ultrasound sampling points, there was no significant difference in urinary 8-oxodG levels between pre- and posttreatment (persistent PDF = 34.6%). Based on a logistic regression model and receiver operation curve analysis, the increase of 8-oxodG levels was found to be associated with increasing risk of PDF. Measurement of urinary 8-oxodG and US increased the likelihood of discovering persistent PDF, which is a predictable condition for the patients at risk of OV-associated CCA. To identify high-risk individuals for CCA, it is useful to perform US in combination with urinary 8-oxodG measurement.
机译：以前的研究表明，尿8-oxodg是用于Opisthorchis viverrini（OV） - 分配的肝胆疾病（HBD）和胆管癌（CCA）的预测生物标志物。本研究检测了吡喹酮治疗对尿8-oxodg与HBD状态相关的影响。通过腹膜超声（US）评估的潜水纤维化（PDF）对患有ov，尿8-oxodg和HBD状态的感染，并将在Praziquantel治疗之前和1年之前进行了肺炎，泰国的参与者的队列。治疗后尿8-oxodg水平显着降低，与没有HBD的ov感染的参与者中的基线水平（PDF阴性; PDF-VE）（n = 14）。在具有阳性PDF的OV感染受试者（OV + VE）中治疗后，8-氧代的水平不变（n = 52）。在阳性PDF（PDF + ve）组内，在治疗后成为PDF-ve的组，预治疗和后处理之间的8-氧代水平没有显着变化（可逆PDF = 65.3％）。在持久性PDF + VE在超声取样点的人中，预治疗和后处理（持久性PDF = 34.6％）之间的尿8-氧代水平没有显着差异。基于Logistic回归模型和接收器操作曲线分析，发现8-氧代水平的增加与增加PDF的风险有关。测量尿8-氧代和美国增加了发现持久性PDF的可能性，这对于患者患者有可预测的病症，患有ob相关的CCA的风险。为了识别CCA的高风险个体，可以与尿8-氧代测量相结合使用。

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