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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Multiple Praziquantel Treatments of Schistosoma mansoni Egg-Negative, CCA-Positive Schoolchildren in a Very Low Endemic Setting in Egypt Do Not Consistently Alter CCA Results
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Multiple Praziquantel Treatments of Schistosoma mansoni Egg-Negative, CCA-Positive Schoolchildren in a Very Low Endemic Setting in Egypt Do Not Consistently Alter CCA Results

机译：多发性血小杂术治疗血吸虫麦昔粒子蛋清，CCA阳性学童在埃及的一个非常低的地方环境中，并不一致地改变CCA结果

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Forty-four Schistosoma mansoni egg-negative/circulating cathodic antigen (CCA) low-positive (trace or 1+) children in three districts of very low prevalence in Egypt were given three sequential praziquantel (PZQ) treatments. Stool and urine specimens were collected 3 months following the initial treatment, and 3 weeks following the second and following the third PZQ treatments, which were conducted 5 weeks apart. Stool specimens were examined by Kato-Katz (four slides/stool sample) and all S. mansoni egg-negative stools were further tested by the "miracidia hatching test" (MHT). Urine samples were examined by the point-of-care CCA assay (POC-CCA). Over the study period, all stool samples from study subjects remained S. mansoni egg negative and MHT negative. Of the POC-CCA test results, in the first day of the study 3 months following the initial treatment, 29.5% were negative, 61.4% CCA trace positives, and 9.1% CCA 1+ positives. Following each PZQ treatment, the test results fluctuated between 1+, trace, and negative, but did not consistently decrease. The proportions of POC-CCA-positive results obtained in the first day (70.5%) as compared with the last day of the study (72.7%) in all of the three districts were very similar. We conclude that CCA trace and 1+ readings, in Kato-Katz S. mansoni egg-negative children in this area with very low levels of intestinal schistosomiasis, are not consistently altered or rendered consistently negative following repeated PZQ treatments and are therefore likely to represent false-positive readings. This finding is of critical importance for countries such as Egypt as they approach elimination.
机译：四十四个血吸虫麦森蛋清蛋清/循环阴极抗原（CCA）在埃及非常低普遍存在的三个地区的低阳性（痕量或1+）儿童进行了三次连续的吡喹酮（PZQ）治疗。在初始治疗后3个月收集粪便和尿样，并在第二个和第三个PZQ治疗后3周，其分开5周。通过Kato-Katz（四个幻灯片/粪便样品）检查粪便标本，并通过“Miracidia孵化试验”（MHT）进一步测试所有S.Mansoni卵负粪便。通过护理点CCA测定（POC-CCA）检查尿液样品。在研究期间，研究受试者的所有粪便样本都留下了曼森卵，阴性和阴性。在初始治疗后3个月的研究中的第一天，29.5％是阴性，CCA痕量阳性，9.1％CCA 1+阳性。在每个PZQ治疗后，测试结果波动在1+，迹线和阴性之间，但并未始终减少。与研究中的最后一天（72.7％）相比，在第一天获得的PoC-CCA阳性结果的比例（70.5％）非常相似。我们得出结论，CCA痕迹和1+读数，在该地区的Kato-Katz S. Mansoni卵阴性儿童中具有非常低的肠血吸虫病，并不始终如一地改变或始终如一地进行负面的阴性，因此可能代表假冒读数。这一发现对埃及等国家在灭绝时至关重要。

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