A Combination of Itraconazole and Amiodarone Is Highly Effective against Trypanosoma cruzi Infection of Human Stem Cell-Derived Cardiomyocytes

GabrieleSass; RoyT. Madigan; Lydia-Marie Joubert; Adriana Bozzi; Nazish Sayed; Joseph C. Wu; David A. Stevens ^dgt; California Institute for Medical Research; San Jose; California

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A Combination of Itraconazole and Amiodarone Is Highly Effective against Trypanosoma cruzi Infection of Human Stem Cell-Derived Cardiomyocytes

机译：伊丙酮和胺碘酮的组合对人干细胞衍生的心肌细胞的锥虫瘤感染具有高度有效性

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Abstract. Trypanosoma cruzi is the etiologic agent of Chagas disease (CD), which can result in severe cardiomy- opathy. Trypanosoma cruzi is endemic to the Americas, and of particular importance in Latin America. In the United States and other non-endemic countries, rising case numbers have also been observed. The currently used drugs are benzni- dazole (BNZ) and nifurtimox, which have limited efficacy during chronic infection. We repurposed itraconazole (ICZ), originally an antifungal, in combination with amiodarone (AMD), an antiarrhythmic, with the goal of interfering with T. cruzi

机译：抽象的。睾丸瘤Cruzi是Chagas疾病（CD）的病因试剂，这可能导致严重的心肌透明度。睾丸瘤Cruzi对美洲有条不紊，特别是拉丁美洲的重要性。在美国和其他非流行国家，也观察到上升的案例数。目前使用的药物是Benzni-Dazole（BNZ）和Nifurtimox，在慢性感染期间具有有限的效果。我们重新培养了伊丙酮（ICZ），最初是一种抗真菌，与胺碘酮（AMD），一种抗心律失常，具有干扰T.Cruzi的目的

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《The American Journal of Tropical Medicine and Hygiene》 |2019年第2期|共9页
作者
GabrieleSass; RoyT. Madigan; Lydia-Marie Joubert; Adriana Bozzi; Nazish Sayed; Joseph C. Wu; David A. Stevens ^dgt; California Institute for Medical Research; San Jose; California;
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1. A Combination of Itraconazole and Amiodarone Is Highly Effective against Trypanosoma cruzi Infection of Human Stem Cell-Derived Cardiomyocytes [J] . GabrieleSass, RoyT. Madigan, Lydia-Marie Joubert, The American Journal of Tropical Medicine and Hygiene . 2019,第2期

机译：伊丙酮和胺碘酮的组合对人干细胞衍生的心肌细胞的锥虫瘤感染具有高度有效性
2. Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as?a?Model to Study Trypanosoma cruzi Infection [J] . Adriana Bozzi, Nazish Sayed, Elena Matsa, Stem Cell Reports . 2019,第6期

机译：使用人诱导的多能干细胞衍生的心肌细胞作为α？模型研究序列瘤Cruzi感染
3. Trypanosoma cruzi infection of human induced pluripotent stem cell-derived cardiomyocytes: an in vitro model for drug screening for Chagas disease [J] . Lara Leonardo da Silva, Andrade-Lima Leonardo, Calvet Claudia Magalhaes, Microbes and infection . 2018,第5期

机译：人诱导人诱导多能干细胞衍生心肌细胞的脑蛋白质瘤瘤瘤感染：对Chagas病的药物筛选体外模型
4. Effect of TGF-beta and TNF-alpha treatment in Trypanosoma cruzi-infected cardiomyocytes: new insights on Chagas' disease extracellular matrix regulation [C] . Calvet C.M, Oliveira, F.O.R., International Congress of Parasitology . 2010

机译：TGF-β和TNF-α治疗在脑瘤瘤瘤瘤感染心肌细胞中的影响：对黏磁疾病细胞外基质调节的新见解
5. Human Embryonic Stem Cell-Derived Cardiomyocytes with Ischemia Resistant Gap Junctions [D] . Jargstorf, Joseph . 2020

机译：人胚胎干细胞衍生的心肌细胞，具有缺血抗隙结
6. 1357. A Combination of Itraconazole and Amiodarone Is Highly Effective Against Trypanosoma cruzi Infection of Human Stem Cell-Derived Cardiomyocytes [O] . Gabriele Sass, Roy Madigan, Adriana Bozzi, -1

机译：1357.伊曲康唑和胺碘酮的组合对人类干细胞来源的心肌细胞的克氏锥虫感染具有很高的抵抗力
7. A Combination of Itraconazole and Amiodarone Is Highly Effective against Trypanosoma cruzi Infection of Human Stem Cell–Derived Cardiomyocytes [O] . Gabriele Sass, Roy T. Madigan, Lydia-Marie Joubert, 2019

机译：伊丙酮和胺碘酮的组合对人干细胞衍生心肌细胞的脑蛋白酶瘤感染具有高度有效
8. An Endemic Focus of 'Trypanosoma cruzi' Infection in a Subhuman Primate Research Colony. [R] . Kasa, T. J., Lathrop, G. D., Dupuy, H. J., 1977

机译：“非人类灵长类动物研究群体”中“克氏锥虫”感染的特点。

A Combination of Itraconazole and Amiodarone Is Highly Effective against Trypanosoma cruzi Infection of Human Stem Cell-Derived Cardiomyocytes

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