...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >A Retrospective Case-Control Study of the Relationship between the Gut Microbiota, Enteropathy, and Child Growth
【24h】

A Retrospective Case-Control Study of the Relationship between the Gut Microbiota, Enteropathy, and Child Growth

机译：肠道微生物，肠病和儿童生长之间关系的回顾性案例控制研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The microbial communities residing in the child gut are thought to play an important role in child growth, although the relationship is not well understood. We examined a cohort of young children from Mirzapur, Bangladesh, prospectively over 18 months. Four fecal markers of environmental enteropathy (EE) (high levels of alpha-1-antitrypsin, calprotectin, myeloperoxidase, and neopterin) were examined and anthropometric measures obtained from a cohort of 68 children. The 16S rRNA gene of bacterial DNA was sequenced from stool samples and used to estimate amplicon sequence variants (ASVs). We age-matched children with poor growth to children with normal growth within 1 month and compared the change in abundance and diversity of ASVs over time. Elevated EE markers and poor linear growth in children were associated with changes in microbial communities in the gut. There were increased amounts of Escherichia/Shigella and Proteobacteria and decreased amounts of Prevotella associated with poorly growing children consistent with the mounting evidence supporting the relationship between intestinal inflammation, child growth, and changes in gut microbiota composition. Future research is needed to investigate this association among young children in low- and middle-income countries.
机译：留在儿童肠道中的微生物社区被认为在儿童增长中发挥着重要作用，尽管这种关系并不充分理解。我们审查了来自孟加拉国的Mirzapur的幼儿队列，前瞻性超过18个月。检查环境肠病（EE）的四种粪便标志物（高水平的α-1-抗抗酸，CalProtectin，髓氧化氢酶和Neopterin），并从68名儿童的队列中获得的人体测量措施。从粪便样品测序细菌DNA的16S rRNA基因，并用于估计扩增子序列变体（ASV）。我们在1个月内对患有正常增长的儿童的增长差异的儿童达到了较差的儿童，并与时间随着时间的推移比较了ASV的丰富和多样性的变化。 ee标记升高和儿童的线性增长差与肠道中微生物群落的变化有关。大量的大肠杆菌和志贺氏菌和植物体外，与伴随肠炎症，儿童生长与肠道微生物组成之间的关系的安装证据一致的儿童符合不良儿童的促进菌和植物菌量的量减少。需要未来的研究来调查低收入和中等收入国家的幼儿之间的这一协会。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号