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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Clinical and Laboratory Characteristics of an Acute Chikungunya Outbreak in Bangladesh in 2017
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Clinical and Laboratory Characteristics of an Acute Chikungunya Outbreak in Bangladesh in 2017

机译：2017年孟加拉国急性Chikungunya爆发的临床和实验室特征

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From April to September 2017, Bangladesh experienced a huge outbreak of acute Chikungunya virus infection in Dhaka. This series describes the clinical and laboratory features of a large number of cases (690; 399 confirmed and 291 probable) suffered during that period. This observational study was carried out at Dhaka Medical College Hospital, Bangladesh. The median age of the patients at presentation was 38 years (IQR 30-50) with a male (57.3%) predominance. Hypertension and diabetes were the most common comorbidities. The mean (+/- SD) duration of fever was 3.7 (+/- 1.4) days. Other common manifestations were arthralgia (99.2%), maculopapular rash (50.2%), morning stiffness (49.7%), joint swelling (48.5%), and headache (37.6%). Cases were confirmed by anti-chikungunya IgG (173; 43.3%), IgM (165; 42.3%), and reverse transcription polymerase chain reaction (44; 11.0%). Important laboratory findings include high erythrocyte sedimentation rate (156; 22.6%), raised serum glutamic pyruvic transaminase (73; 10.5%), random blood sugar (54; 7.8%), leukopenia (72; 10.4%), thrombocytopenia (41; 5.9%), and others. The oligo-articular (453; 66.1%) variety of joint involvement was significantly more common compared with the poly-articular (237; 34.5%) variety. Commonly involved joints were the wrist (371; 54.1%), small joints of the hand (321; 46.8%), ankle (251; 36.6%), knee (240; 35.0%), and elbow (228; 33.2%). Eleven cases were found to be complicated with neurological involvement and two of them died. Another patient died due to myocarditis. Public health experts, clinicians, and policymakers could use the results of this study to construct the future strategy tackling chikungunya in Bangladesh and other epidemic countries.
机译：从4月到2017年9月，孟加拉国在达卡急剧爆发了急性Chikungunya病毒感染。本系列描述了大量情况的临床和实验室特征（690; 399确认，291个可能）在此期间遭受。该观察研究是在孟加拉国达卡医学院医院进行的。介绍的患者的中位年龄为38岁（IQR 30-50），男性（57.3％）优势。高血压和糖尿病是最常见的合并症。发烧的平均值（+/-sd）持续时间为3.7（+/- 1.4）天。其他常见表现为关节痛（99.2％），marupopapular皮疹（50.2％），晨刚度（49.7％），关节肿胀（48.5％）和头痛（37.6％）。抗Chikungunya IgG（173; 43.3％），IgM（165; 42.3％）和逆转录聚合酶链反应（44; 11.0％）确认病例。重要的实验室发现包括高红细胞沉降率（156; 22.6％），升高的血清谷氨酸丙酮转氨酶（73; 10.5％），随机血糖（54; 7.8％），白细胞减少（72; 10.4％），血小板减少症（41; 5.9 ％）， 和别的。与多关节（237,34.5％）品种相比，寡核关节（453; 66.1％）各种关节参与的常见程度明显更为常见。通常涉及的关节是手腕（371; 54.1％），手的小关节（321; 46.8％），踝关节（251; 36.6％），膝关节（240; 35.0％）和肘部（228; 33.2％）。发现11例患者复杂于神经侵扰和其中两种死亡。另一名患者因心肌炎而死。公共卫生专家，临床医生和政策制定者可以利用本研究的结果来构建孟加拉国和其他流行国家的未来战略解决Chikungunya。

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